Extra-nasal Colonization and Epidemiology of Community-Associated MRSA

社区相关 MRSA 的鼻外定植和流行病学

• 批准号: 8441538
• 负责人: Kyle Jeanne Popovich
• 金额: $ 12.94万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441538
• 关键词: Admission activity; Adult; Affect; Age; Age-Years; Anterior nares; Award; Biometry; Centers for Disease Control and Prevention (U.S.); Chicago; Clinical; Clinical Investigator; Clinical Microbiology; Communicable Diseases; Communities; Community Hospitals; Computational algorithm; County; County Hospitals; Development; Disease; Environment; Epidemic; Epidemiologic Studies; Epidemiologist; Epidemiology; Funding; Future; Gel; Goals; HIV; Health; Health care facility; Healthcare; High Prevalence; Hospitals; Illinois; Individual; Infection; Infection Control; Infection prevention; Integration Host Factors; International; Intervention Studies; Investigation; Knowledge; Lead; Manuscripts; Master of Science; Medicine; Mentors; Mentorship; Michigan; Monobactams; Nature; Nose; Nosocomial Infections; Oral; Pathogenesis; Patients; Pattern; Peer Review; Physiologic pulse; Play; Pneumonia; Policies; Population; Prevalence; Prevention; Prevention Measures; Prevention strategy; Preventive Intervention; Public Health Schools; Publishing; Relative (related person); Research; Research Infrastructure; Research Methodology; Research Personnel; Resistance; Resources; Role; Sepsis; Site; Staphylococcus aureus; System; Testing; Universities; Virulence Factors; Work; abstracting; base; career; career development; cohort; cooking; demographics; editorial; electronic data; epidemiologic data; experience; instructor; interdisciplinary approach; interest; meetings; member; methicillin resistant Staphylococcus aureus; patient population; professor; research and development; skills; surveillance strategy; transmission process; young adult

DESCRIPTION (provided by applicant): Dr. Kyle Popovich, Clinical Instructor in the Department of Medicine at Rush University (RUMC), seeks support for research and career development to establish a career as an independent clinical investigator in the field of hospital epidemiology. Her research interest is community-associated methicillin-resistant S.aureus (CA-MRSA); she has been the first author on 4 peer-reviewed manuscripts, has published 2 review articles and co-authored and been the sole author of 2 editorials on CA-MRSA, and has presented 6 abstracts of her work in oral scientific sessions at national meetings. Dr. Popovich will work under the mentorship of Dr. Robert Weinstein, an international leader in healthcare epidemiology; Mary Hayden, MD (co-mentor), Director, Division of Clinical Microbiology, RUMC and an accomplished researcher in hospital epidemiology; and Dr. Bala Hota (co-mentor), an investigator with expertise in biostatistics and computer algorithms for infection surveillance. In addition to this core interdisciplinary mentorship team, 4 advisory members will critically evaluate research and career development-Dr. Scott Fridkin of the CDC; Dr. Sharon Welbel, Hospital Epidemiologist in the Cook County Health and Hospitals System; Dr. Carol Kauffman, Professor of Medicine (Infectious Diseases), University of Michigan; and Dr. Gordon Trenholme, Director, Section of Infectious Diseases, RUMC. Dr. Popovich is acquiring new skills in research methodology and biostatistics by currently taking classes toward a Masters of Science in Epidemiology at the University of Illinois at Chicago, School of Public Health. She is working in a well-funded, nurturing environment that has produced major epidemiologic and intervention studies of healthcare-associated infections. The strong existing infrastructure for collaborative research between Cook County Hospital and RUMC and the interdisciplinary approach of Dr. Popovich's proposal will allow her to develop the essential skills and experience needed to become an independent researcher capable of applying for an R-01 at the end of the award period. In prior studies, Dr. Popovich demonstrated that CA-MRSA strains are replacing traditional hospital MRSA strains as causes of nosocomial infection. The CA-MRSA epidemic is currently disproportionately affecting particular patient populations (e.g., younger adults). This proposal is an extension of this and has 2 aims: (1) determine the extent to which CA-MRSA strains colonize extra-nasal sites and (2) determine the extent to which exclusive extra-nasal CA-MRSA colonization occurs among patients age = 30. Hypotheses are: (1) prevalence of extra-nasal colonization with CA-MRSA strains is higher than that of non-CA-MRSA strains and (2) a cohort of patients age = 30 will have a 3.5 fold greater prevalence of extra-nasal CA-MRSA colonization in comparison to a patients age>30. To test these hypotheses, colonization surveillance and an established electronic data warehouse will be used. Findings will inform a future project (R-01) examining the origin of CA-MRSA strains causing nosocomial infections and testing infection prevention strategies for reducing spread of the CA-MRSA epidemic. Relevance: While originally affecting individuals without prior healthcare exposures, the community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) epidemic has emerged as a cause of invasive infection in the hospital, with particular populations being disproportionately affected. The goal of this project is to further characterize the epidemiology and colonizaiton dynamics of CA-MRSA strains in order develop and test prevention strategies in hospital settings.

描述（由申请人提供）：Rush University（RUMC）医学系临床讲师Kyle Popovich博士寻求研究和职业发展的支持，以建立医院流行病学领域的独立临床研究者的职业。她的研究兴趣是与社区相关的耐甲氧西林（CA-MRSA）；她曾是4个同行评审的手稿的第一位作者，曾发表了2篇评论文章，并由合着并成为CA-MRSA的2位社论的唯一作者，并在全国会议上介绍了她在口头科学课程中的6个摘要。 Popovich博士将在医疗保健流行病学国际领导者Robert Weinstein博士的指导下工作；玛丽·海登（Mary Hayden），医学博士（联合学），RUMC临床微生物学系主任，也是医院流行病学专业的研究人员；以及Bala Hota博士（Co-Incertor），该研究人员在生物统计学和计算机算法方面具有专业知识，用于感染监视。除了这个核心跨学科指导团队外，4位咨询会员还将对研究和职业发展进行严格评估。 CDC的Scott Fridkin；库克县健康与医院系统医院流行病学家Sharon Welbel博士；密歇根大学医学教授（传染病）教授Carol Kauffman博士； Rumc传染病部分主任Gordon Trenholme博士。 Popovich博士目前在伊利诺伊大学的公共卫生学院伊利诺伊大学攻读流行病学科学硕士学位，从而获得了研究方法和生物统计学的新技能。她正在一个资金丰富，养育的环境中工作，该环境已经产生了有关医疗保健相关感染的主要流行病学和干预研究。库克县医院与RUMC之间的合作研究以及Popovich博士提议的跨学科方法的强大基础设施将使她能够发展成为能够在奖励期结束时申请R-01的独立研究人员所需的基本技能和经验。在先前的研究中，Popovich博士表明，CA-MRSA菌株正在取代传统医院MRSA菌株作为医院感染的原因。 CA-MRSA流行目前对特定患者人群（例如年轻人）的影响不成比例。该提议是对此的扩展，并且具有2个目的：（1）确定CA-MRSA在多大程度上定居于鼻腔外部位，并且（2）确定患者之间出现独特的鼻腔外CA-MRSA殖民化的程度。与年龄> 30岁的患者相比，年龄= 30岁的患者队列= 30岁将使鼻外CA-MRSA定殖的患病率更高。为了检验这些假设，将使用定植监视和已建立的电子数据仓库。调查结果将为未来的项目（R-01）提供研究，以检查引起医院感染的CA-MRSA菌株的起源，并测试预防预防感染策略，以减少CA-MRSA流行病的传播。 相关性：虽然最初影响没有事先医疗保健暴露的个体，但与社区相关的耐甲氧西林金黄色葡萄球菌（CA-MRSA）流行已经成为医院侵入性感染的原因，特定人群受到了不成比例的影响。该项目的目的是进一步描述CA-MRSA菌株的流行病学和殖民地动力学，以制定和测试医院环境中的预防策略。