Patient Oriented Research Program in ALI/ARF

ALI/ARF 以患者为中心的研究计划

• 批准号: 8531326
• 负责人: MARC MOSS
• 金额: $ 14.08万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531326
• 关键词: Acute; Acute Lung Injury; Acute respiratory failure; Adult Respiratory Distress Syndrome; Affect; Alcohol abuse; Alcohols; Alveolar Macrophages; Apoptotic; Award; Caring; Cells; Cities; Commit; Conduct Clinical Trials; Critical Illness; Data; Deglutition; Deglutition Disorders; Development; Development Plans; Diagnosis; Diagnostic; Enrollment; Environmental air flow; Evaluation; Fostering; Functional disorder; Funding; Future; Grant; Growth; Human; Impairment; Individual; Inflammatory; Lead; Leadership; Lung; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Monitor; National Heart, Lung, and Blood Institute; Nature; Outcome; Oxidants; Patient Care; Patients; Peripheral; Phase; Positioning Attribute; Predisposition; Productivity; Publishing; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resolution; Site; Study Section; Techniques; Testing; Training; Translational Research; United States; United States National Institutes of Health; Vision; Water; Work; abstracting; base; career; career development; comparative effectiveness; cost; editorial; effectiveness research; improved; interest; meetings; multidisciplinary; neuromuscular; next generation; novel; patient oriented; patient oriented research; programs; research study; skills; success; translational study

Acute lung injury (ALI) is a severe form of pulmonary impairment affecting 200,000 people annually in the United States. Acute respiratory failure (ARF) is an even more common type of pulmonary dysfunction characterized by profound alterations in oxygenation and ventilation. Though advances in the care of these critically ill patients have occurred, further cultivation of patient-oriented investigators with an interest in ALI/ARF will be necessary to generate significant improvements in the outcomes of these patients. Mentoring is by far the most important and fulfilling component of my current academic position. I am completely committed to mentoring, inherently enjoy developing mutual visions of success with my trainees, and appreciate the opportunity to make a difference in their lives and careers. With the support of my present K24, I have already served as the primary mentor or co-mentor for 16 junior or mid-level investigators performing ALI/ARF patient-oriented research. A total of 88% (14/16) of them remain in academic medicine. In less than four years, these trainees have received 4 new grants in excess of $5,000,000 and have 4 more NIH grants under review or ready for resubmission. They have also authored 24 research articles, 9 review articles/editorials, 5 research articles presently under submission, and 29 ATS abstracts on which I am the senior or a co-author. Despite our productivity, several new programs are proposed in this competitive renewal that will further enhance my career development and the training for all of our present and future trainees. With the creation of our city-wide research network, we are well positioned to perform comparative effectiveness research (CER) studies. In order to properly lead these efforts, I will need to boost my skills in CER research. Our increasing number of mid-level investigators will require advanced training in mentoring and leadership skills in order to prepare them to become the next generation of ALI/ARF mentors. In addition, I will create new training opportunities for our more junior investigators and work to attract trainees from other multidisciplinary fields. In this renewal, we also propose two research studies that will lead to improvements in the care of our ALI/ARF patients. The first study will build upon our existing interest in peripheral neuromuscular dysfunction in ALI/ARF patients and determine the utility of simple bedside techniques for the diagnosis of swallowing dysfunction that is common and debilitating in our patients. In the second translational study, we will continue to explore the mechanisms by which alcohol alters the susceptibility to develop ALI and determine whether alcohol abuse alters the clearance of apoptotic inflammatory cells during the resolution phase of ALI through oxidant-dependent RhoA activation. With the support of this competitive renewal, I will be able to continue to develop our research program and ultimately establish ourselves as one of the premier ALI/ARF research groups in the United States.

急性肺损伤 (ALI) 是一种严重的肺损伤，每年影响美国 20 万人。急性呼吸衰竭（ARF）是一种更常见的肺功能障碍类型，其特征是氧合和通气的深刻改变。尽管这些危重患者的护理已经取得了进展，但仍需要进一步培养对 ALI/ARF 感兴趣的以患者为中心的研究人员，以显着改善这些患者的治疗结果。迄今为止，指导是我当前学术职位中最重要和最有成就感的部分。我完全致力于指导，本质上喜欢与我的学员发展共同的成功愿景，并且很高兴有机会改变他们的生活和职业生涯。在我目前的 K24 的支持下，我已经担任 16 名初级或中级研究人员的主要导师或共同导师，进行 ALI/ARF 患者导向的研究。其中 88% (14/16) 仍从事学术医学工作。在不到四年的时间里，这些学员获得了 4 项超过 5,000,000 美元的新资助，并且还有 4 项 NIH 资助正在接受审查或准备重新提交。他们还撰写了 24 篇研究文章、9 篇评论文章/社论、5 篇目前正在提交的研究文章以及 29 篇 ATS 摘要（我是其中的资深作者或共同作者）。尽管我们生产力很高，但在这次竞争性更新中提出了几个新计划，这将进一步加强我的职业发展以及对我们所有现有和未来学员的培训。随着我们全市研究网络的建立，我们已经做好了开展比较有效性研究（CER）的准备。为了正确领导这些工作，我需要提高我在 CER 研究方面的技能。我们越来越多的中级调查员需要接受指导和领导技能方面的高级培训，以便让他们做好成为下一代 ALI/ARF 导师的准备。此外，我将为我们的初级研究人员创造新的培训机会，并努力吸引来自其他多学科领域的学员。在本次更新中，我们还提出了两项​​研究，这将改善我们的 ALI/ARF 患者的护理。第一项研究将建立在我们对 ALI/ARF 患者周围神经肌肉功能障碍的现有兴趣的基础上，并确定简单的床边技术在诊断吞咽功能障碍中的效用，吞咽功能障碍在我们的患者中常见且使人衰弱。在第二项转化研究中，我们将继续探索酒精改变 ALI 易感性的机制，并确定酒精滥用是否通过氧化剂依赖性 RhoA 激活，在 ALI 消退阶段改变凋亡炎症细胞的清除。在这一竞争性更新的支持下，我将能够继续发展我们的研究项目，并最终将我们打造成美国首屈一指的 ALI/ARF 研究小组之一。