Patient Oriented Research Program in ALI/ARF

ALI/ARF 以患者为中心的研究计划

• 批准号: 8531326
• 负责人: MARC MOSS
• 金额: $ 14.08万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531326
• 关键词: Acute; Acute Lung Injury; Acute respiratory failure; Adult Respiratory Distress Syndrome; Affect; Alcohol abuse; Alcohols; Alveolar Macrophages; Apoptotic; Award; Caring; Cells; Cities; Commit; Conduct Clinical Trials; Critical Illness; Data; Deglutition; Deglutition Disorders; Development; Development Plans; Diagnosis; Diagnostic; Enrollment; Environmental air flow; Evaluation; Fostering; Functional disorder; Funding; Future; Grant; Growth; Human; Impairment; Individual; Inflammatory; Lead; Leadership; Lung; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Monitor; National Heart, Lung, and Blood Institute; Nature; Outcome; Oxidants; Patient Care; Patients; Peripheral; Phase; Positioning Attribute; Predisposition; Productivity; Publishing; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resolution; Site; Study Section; Techniques; Testing; Training; Translational Research; United States; United States National Institutes of Health; Vision; Water; Work; abstracting; base; career; career development; comparative effectiveness; cost; editorial; effectiveness research; improved; interest; meetings; multidisciplinary; neuromuscular; next generation; novel; patient oriented; patient oriented research; programs; research study; skills; success; translational study

Acute lung injury (ALI) is a severe form of pulmonary impairment affecting 200,000 people annually in the United States. Acute respiratory failure (ARF) is an even more common type of pulmonary dysfunction characterized by profound alterations in oxygenation and ventilation. Though advances in the care of these critically ill patients have occurred, further cultivation of patient-oriented investigators with an interest in ALI/ARF will be necessary to generate significant improvements in the outcomes of these patients. Mentoring is by far the most important and fulfilling component of my current academic position. I am completely committed to mentoring, inherently enjoy developing mutual visions of success with my trainees, and appreciate the opportunity to make a difference in their lives and careers. With the support of my present K24, I have already served as the primary mentor or co-mentor for 16 junior or mid-level investigators performing ALI/ARF patient-oriented research. A total of 88% (14/16) of them remain in academic medicine. In less than four years, these trainees have received 4 new grants in excess of $5,000,000 and have 4 more NIH grants under review or ready for resubmission. They have also authored 24 research articles, 9 review articles/editorials, 5 research articles presently under submission, and 29 ATS abstracts on which I am the senior or a co-author. Despite our productivity, several new programs are proposed in this competitive renewal that will further enhance my career development and the training for all of our present and future trainees. With the creation of our city-wide research network, we are well positioned to perform comparative effectiveness research (CER) studies. In order to properly lead these efforts, I will need to boost my skills in CER research. Our increasing number of mid-level investigators will require advanced training in mentoring and leadership skills in order to prepare them to become the next generation of ALI/ARF mentors. In addition, I will create new training opportunities for our more junior investigators and work to attract trainees from other multidisciplinary fields. In this renewal, we also propose two research studies that will lead to improvements in the care of our ALI/ARF patients. The first study will build upon our existing interest in peripheral neuromuscular dysfunction in ALI/ARF patients and determine the utility of simple bedside techniques for the diagnosis of swallowing dysfunction that is common and debilitating in our patients. In the second translational study, we will continue to explore the mechanisms by which alcohol alters the susceptibility to develop ALI and determine whether alcohol abuse alters the clearance of apoptotic inflammatory cells during the resolution phase of ALI through oxidant-dependent RhoA activation. With the support of this competitive renewal, I will be able to continue to develop our research program and ultimately establish ourselves as one of the premier ALI/ARF research groups in the United States.

急性肺损伤（ALI）是一种严重的肺部损伤形式，每年在美国影响200,000人。急性呼吸衰竭（ARF）是一种更常见的肺功能障碍类型，其特征是氧合和通风的深刻改变。尽管已经发生了这些重症患者的护理进步，但仍需要进一步培养对患者/ARF感兴趣的患者研究人员，以对这些患者的结局产生显着改善。迄今为止，指导是我当前学术职位中最重要，最充实的组成部分。我完全致力于指导，固有地喜欢与学员共同发展成功的愿景，并感谢有机会改变他们的生活和职业。在我目前的K24的支持下，我已经担任了16名初级或中级研究人员的主要导师或同事，从事ALI/ARF以患者为导向的研究。总共88％（14/16）仍在学术医学中。在不到四年的时间里，这些受训者获得了4份新的赠款，超过5,000,000美元，并在审查中又有4份NIH赠款或准备重新提交。他们还撰写了24篇研究文章，9篇评论文章/社论，目前在提交中的5篇研究文章以及我是高级或合着者的29个ATS摘要。尽管我们的生产力，但在这种竞争性更新中提出了一些新计划，这将进一步增强我的职业发展和对我们目前和未来的学员的培训。通过建立我们在全市范围的研究网络的建立，我们在进行比较有效性研究（CER）研究方面处于良好状态。为了正确地领导这些努力，我需要提高我的CER研究技能。我们越来越多的中级调查人员将需要在指导和领导技能方面进行高级培训，以便使他们成为下一代ALI/ARF导师。此外，我将为更多的初级调查人员创造新的培训机会，并努力吸引其他多学科领域的受训者。在此续约中，我们还提出了两项​​研究，这些研究将导致我们的ALI/ARF患者的护理改善。第一项研究将基于我们对ALI/ARF患者的周围神经肌肉功能障碍的现有兴趣，并确定简单的床边技术的实用性，用于诊断我们患者常见且令人衰弱的吞咽功能障碍。在第二次翻译研究中，我们将继续探索酒精会改变发展ALI的易感性的机制，并确定酒精滥用在ALI通过氧化剂依赖性RhoA激活的分辨率阶段是否会改变凋亡炎症细胞的清除。在这一竞争性更新的支持下，我将能够继续制定我们的研究计划，并最终将自己确立为美国主要的ALI/ARF研究小组之一。