SYSTEMS GENETICS AND GENOMICS OF LUNG DISEASES

肺部疾病的系统遗传学和基因组学

• 批准号: 8575264
• 负责人: Edwin K Silverman
• 金额: $ 12.42万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8575264
• 关键词: Area; Asthma; Bioinformatics; Biology; Biometry; Boston; Chronic; Chronic Obstructive Airway Disease; Complex; Computational Biology; Disease; Faculty; Funding; Genetic; Genetic Medicine; Genetic Predisposition to Disease; Genomics; Hospitals; Individual; Knowledge; Lead; Life; Link; Lung diseases; Maps; Medicine; Mentored Clinical Scientist Development Program; Mentors; Methods; National Heart, Lung, and Blood Institute; Pediatric Hospitals; Pharmacogenetics; Positioning Attribute; Proteomics; Public Health; Public Health Schools; Research; Research Personnel; Research Project Grants; Research Training; SECTM1 gene; Science; System; Systems Biology; Training; Training Programs; Woman; base; career; clinical epidemiology; design; epigenomics; genome wide association study; medical schools; meetings; metabolomics; network models; operation; programs; respiratory; transcriptomics

DESCRIPTION (provided by applicant): This training program is an extension of a program currently funded by NHLBI K12 HL089990 ("Translational Genetics and Genomics of Airways Diseases"). This K12 program, which has operated successfully for the past 5 years, is closely linked with our T32 HL007427 program ("Clinical Epidemiology of Lung Diseases"), which has been in continuous operation for 37 years. Both of these training programs focus on systems genetics and genomics of chronic respiratory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD), which are major public health problems. Asthma and COPD are linked via common environmental and genetic susceptibility; these factors influence disease expression throughout life. Based on our current knowledge of complex diseases, there is a critical need for individuals trained in the application of systems and integrative genomic methods to perform quantitative research in respiratory biology. Therefore, we propose to revise and extend our current K12 training program with an increased emphasis on systems biology, network science, and multiple -omics approaches. The proposed K12 program will be instrumental in meeting the need for increased computational biology expertise in respiratory disease research by successfully training independent research investigators who will go on to lead their own research programs across the U.S.. The proposed K12 program provides research training in six major areas: (1) Systems Genetics (GWAS, Fine Mapping, and Pharmacogenetics); (2) Functional Genetics; (3) Emerging -Omics (Proteomics/Metabolomics/Microbiomics); (4) Transcriptomics, including integrative genomics; (5) Epigenomics; and (6) Systems Biology/Network Modeling. Two Scholar slots are requested in this proposal. The Scholars interact with a pool of 31 core faculty mentors in the six interrelated research areas. Each Scholar will have the opportunity to become involved in the design, execution, and analysis of ongoing federally and non-federally funded research projects, as well as develop an independent career path. Scholars' research is conducted in the Channing Division of Network Medicine, a research division of the Department of Medicine at Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS). After completing our program, K12 Scholars will be eligible to assume faculty positions in systems genetics and genomics. Scholars benefit from a close relationship with the Departments of Biostatistics at the Harvard School of Public Health, the Program in Bioinformatics at Children's Hospital Boston and the Partners Center for Personalized Genetic Medicine. In the past 5 years, we have had 100% retention of K12 trainees in faculty positions and 62 % who have moved on to completely independent funding.

描述（由申请人提供）：该培训计划是由NHLBI K12 HL089990资助的计划的扩展（“流动疾病的转化遗传学和基因组学”）。该K12计划在过去5年中成功运作，与我们的T32 HL007427计划（“肺部疾病的临床流行病学”）密切相关，该计划已经连续运行了37年。这两个培训计划都集中在慢性呼吸道疾病的系统遗传学和基因组学上，尤其是哮喘和慢性阻塞性肺疾病（COPD），这是主要的公共卫生问题。哮喘和COPD通过共同的环境和遗传敏感性连接；这些因素会影响疾病一生的表达。基于我们当前对复杂疾病的了解，对于在系统应用中接受培训的个体和综合基因组方法培训以进行呼吸生物学的定量研究。因此，我们建议对当前的K12培训计划进行修改和扩展，并越来越重视系统生物学，网络科学和多种摩学方法。拟议的K12计划将通过成功培训独立研究研究人员来满足呼吸道疾病研究中提高计算生物学专业知识的需求，这些研究人员将继续领导自己在美国的研究计划。拟议的K12计划在六个主要领域提供了研究培训：（1）系统遗传学（GWAS，细微的映射和药物基础图）； （2）功能遗传学； （3）新兴 - 组（蛋白质组学/代谢组学/微生物学）； （4）转录组学，包括综合基因组学； （5）表观基因组学； （6）系统生物学/网络建模。该提案中要求两个学者插槽。学者与六个相互关联的研究领域中的31位核心教师指导者互动。每个学者将有机会参与正在进行的联邦和非养育研究项目的设计，执行和分析，并发展独立的职业道路。学者的研究是在Brigham and Hospital（BWH）和哈佛医学院（HMS）的医学系Channing Network Medicine的Channing部门进行的。完成我们的计划后，K12学者将有资格在系统遗传学和基因组学中担任教师职位。学者们受益于哈佛公共卫生学院的生物统计学系，波士顿儿童医院的生物信息学计划以及个性化基因医学中心的生物信息学计划。在过去的5年中，我们在教师职位上有100％保留K12学员，而有62％的学员继续获得了完全独立的资金。