Epidemiologic Architedure of Lung Cancer and Smoking

肺癌与吸烟的流行病学结构

• 批准号: 8550776
• 负责人: Christopher I. Amos
• 金额: $ 51.55万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550776
• 关键词: 15q25; Accounting; Adenocarcinoma; African; Age; Architecture; Area; Aromatic Hydrocarbons; Asbestos; Asia; Asians; Australia; Behavioral Genetics; Biochemical; Biological; Biological Markers; Breast; Breathing; Calibration; Cancer Etiology; Cancer Model; Carcinogen exposure; Case-Control Studies; Categories; Cells; Cessation of life; Characteristics; Chemoprevention; Chromosomes, Human, Pair 5; Chronic Obstructive Airway Disease; Chronic lung disease; Cigar Smoking; Cigarette; Cohort Studies; Colon Carcinoma; Comorbidity; Complex; Consensus; Country; Data; Detection; Development; Diagnosis; Diet; Discrimination; Disease; Dose; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Environmental Tobacco Smoke; Epidemiologic Studies; Epidemiology; Ethnic Origin; Europe; European; Exposure to; Family history of; Gender; Gene Frequency; General Population; Genes; Genetic; Genetic Polymorphism; Genetic Risk; Genetic Variation; Geographic Locations; Goals; Grant; Health Benefit; Heavy Metals; Heterogeneity; Iceland; Individual; Intake; Intervention; Joints; Light; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Maps; Measurement; Measures; Medical; Medical History; Meta-Analysis; Metric; Modeling; Nicotine; Nicotine Dependence; North America; Occupational Exposure; Participant; Patient Self-Report; Performance; Phenotype; Population; Population Attributable Risks; Population Heterogeneity; Predisposition; Probability; Procedures; Process; Prostate; Public Health; Publishing; Race; Radon; Recording of previous events; Relative (related person); Research; Research Design; Residual state; Resources; Risk; Risk Factors; Sample Size; Sampling; Sex Characteristics; Signal Transduction; Smoke; Smoker; Smoking; Smoking Behavior; Smoking Status; Specimen; Squamous Cell; Stage at Diagnosis; Staging; Structure; Subgroup; Survival Rate; Testing; Time; Tobacco smoke; Tobacco-Associated Carcinogen; Variant; Work; base; cancer risk; case control; cell type; cohort; cost; disease characteristic; disorder risk; follow-up; fruits and vegetables; gene environment interaction; genetic association; genome wide association study; high risk; improved; indexing; insight; lung carcinogenesis; melanoma; mortality; never smoker; non-smoker; pipe smoking; population based; programs; prospective; racial and ethnic; residence; risk variant; screening; sex; tool; urinary

Finally, in area 3 we propose to perform detailed studies to charaderize the effeds of genetic variation on risk for lung cancer, allowing for effects from tobacco smoke and a limited set of additional environmental exposures that have been collected as a part of ILCCO. We will also explore the effects of genetic variation on smoking phenotypes. Area 3 analyses will allow a careful assessment of the joint effects of smoking and genetic exposures for a range of populations having different smoking behaviors, genetic backgrounds and effects from potential confounding fadors such as diet that have been measured in many cases, but with imprecision. In addition, we will be evaluating existing procedures for characterizing the risk for lung cancer according to age, sex, smoking behavior and demographic and medical history factors. We will also extend these models to include the results from the proposed genetic studies that we are conduding. The final product will be the development of a clearer view of lung carcinogenesis as well as better tools for identifying individuals at high risk to develop lung cancer. Identifying such people is an important goal, since there remain no approved screening mortalities for lung cancer in asymptomatic individuals because of a low positive predidive value of such approaches in the general population, and concern about the potential risks and costs associated with screening.

最后，在区域3中，我们建议进行详细的研究，以使肺癌风险的遗传变化造成范围，从而允许烟草烟雾的影响以及有限的额外环境暴露，这些额外的环境暴露已被收集为ILCCO的一部分。我们还将探索遗传变异对吸烟表型的影响。区域3分析将仔细评估吸烟和遗传暴露的关节影响，以范围对具有不同吸烟行为的种群，遗传背景以及潜在混杂的时代（例如在许多情况下都测量过的饮食）的影响，但不精确。此外，我们将评估现有程序，以表征根据年龄，性别，吸烟行为以及人口统计学和病史因素的肺癌风险。我们还将扩展这些模型，以包括我们所提出的遗传研究的结果。最终产品将是对肺癌发生的更清晰视图的发展，以及更好地识别患有高风险肺癌的个体的工具。确定此类人是一个重要的目标，因为由于这种方法在普通人群中的积极预测价值较低，因此尚无批准的肺癌死亡率筛查死亡率，并且担心与筛查相关的潜在风险和成本。