Neonatal Neurobehavioral Impacts of Iodine Insufficiency and Pesticide Exposures

碘不足和农药暴露对新生儿神经行为的影响

• 批准号: 8111068
• 负责人: Susan Woskie
• 金额: $ 11.71万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111068
• 关键词: Address; Adverse effects; Agriculture; Applications Grants; Behavior assessment; Birth; Blood specimen; Carbamates; Categories; Child; Childhood; Cholinesterases; Collaborations; Communication; Developing Countries; Development; Dietary Iodine; Disease; Educational workshop; Electroencephalogram; Environmental Exposure; Enzymes; Epidemiologic Studies; Event-Related Potentials; Exposure to; Faculty; Fetal Development; Fetal Neurobehavioral Development; Focus Groups; Goals; Goiter; Government; Grant; Health; Hemoglobin concentration result; Hospitals; Human Development; Human Milk; Immunization; Individual; Infant; Intake; International; Interview; Iodine; Joints; Knowledge; Massachusetts; Measurement; Measures; Methods; Monitor; Mothers; Neonatal; Neurologic; Newborn Infant; Nutritional; Organophosphates; Perinatal Exposure; Pesticides; Pilot Projects; Population; Pregnant Women; Prenatal care; Prevention; Prevention program; Prospective Studies; Province; Public Health; Questionnaires; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Sampling; Students; Surveys; Testing; Thailand; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyrotropin; Umbilical Cord Blood; United States National Institutes of Health; Universities; Urine; Visit; Woman; Work; Workplace; drinking water; experience; fetal; follow-up; hazard; in utero; interest; iodine deficiency syndrome; meetings; neonate; neurobehavioral; neurobehavioral test; neurodevelopment; nutrition; pesticide exposure; pesticide poisoning; policy implication; prospective; public health relevance; response; urinary

DESCRIPTION (provided by applicant): The neonatal and childhood neurological effects of severe maternal or fetal thyroid deficiency, which may be caused by low dietary iodine, are well established. Independently, exposure to pesticides can also reduce thyroid hormone, and may exacerbate the effects of low iodine. The combination of these environmental insults may lower thyroid hormone to the extent that fetal neurobehavioral development is significantly impacted. Although Thailand has made great advances in decreasing pesticide poisoning and reducing iodine deficiency disorders (IDD), there are still many pregnant women who experience exposure to pesticides through maternal agricultural work and maternal intake of pesticide contaminated drinking water, and all of the provinces in Thailand have newborns born with iodine deficiency disorders. Considering the importance of thyroid hormones in neurobehavioral development, our main hypothesis is that pesticide exposure increases the impact of iodine insufficiency on neurodevelopment as measured in newborns by the Brazelton Newborn Behavioral Assessment Survey (BNBAS) and in 3-4 month olds by EEG/ERP (Electroencephalogram/Event Related Potential) testing. The main objectives of this planning grant are: 1) to develop and strengthen a partnership of multi-disciplinary, international researchers in Thailand and the U.S. focused on the recognition, prevention and treatment of environmental and nutritional causes of neurobehavioral deficits among Thai infants and young children; 2) to demonstrate the feasibility of conducting a prospective epidemiologic study to assess the impact of maternal/fetal sub-optimal iodine levels and pesticide exposures on thyroid hormone levels and neonatal neurobehavioral development. As part of our capacity building efforts we will establish a joint research Center for Work Environment and Nutrition in Human Development at the Mahidol Faculty of Public Health to facilitate researcher and student exchanges and collaboration. For our pilot research project, 108 pregnant women will be recruited from provincial hospitals in 3 provinces. They will be asked for information on nutrition, pesticide exposures and other potential confounders. The women will provide urine and blood samples and at birth a placental cord blood sample will be collected. Samples will be analyzed for iodine, pesticide and thyroid hormone levels. Newborns will undergo neurobehavioral testing with the BNBAS. When they return for routine 3-4 month immunizations, infants will undergo neurobehavioral testing using an EEG/ERP test battery. Breast milk will be collected from mothers for pesticide and iodine measurements. Our objective is to use this pilot study to launch a prospective study of the impact of iodine insufficiency, pesticide exposure and other potential nutritional and environmental influences, on Thai children's neurodevelopment. Additionally, a long term goal of this research is to work with the Thai Ministry of Health to develop and test prevention programs focused on prenatal care settings. PUBLIC HEALTH RELEVANCE: Not only is it of scientific interest to examine the role of environmental conditions (iodine availability and pesticide exposures) on the thyroid and subsequent fetal development, but it also may have important policy implications for public health. Developing countries have limited resources available to address a wide range of public health problems including IID and pesticide hazards. Better knowledge of the adverse effects of the interaction of pesticide exposures and iodine insufficiency will allow for more informed decisions by doctors, individuals and government public health officers and regulators.

描述（由申请人提供）：严重的母体或胎儿甲状腺缺乏症（可能由低膳食碘引起）对新生儿和儿童神经系统的影响已得到充分证实。另外，接触杀虫剂也会降低甲状腺激素，并可能加剧低碘的影响。这些环境损害的结合可能会降低甲状腺激素，从而严重影响胎儿的神经行为发育。尽管泰国在减少农药中毒和减少碘缺乏病（IDD）方面取得了巨大进步，但仍有许多孕妇因孕产妇从事农业工作和摄入受农药污染的饮用水而接触农药，并且泰国所有省份都存在接触农药的情况。新生儿出生时患有碘缺乏症。 考虑到甲状腺激素在神经行为发育中的重要性，我们的主要假设是，根据 Brazelton 新生儿行为评估调查 (BNBAS) 测量的新生儿以及通过 EEG/ERP 测量的 3-4 个月大的婴儿，农药暴露会增加碘不足对神经发育的影响（脑电图/事件相关电位）测试。该规划拨款的主要目标是：1）发展和加强泰国和美国多学科国际研究人员的合作伙伴关系，重点关注泰国婴儿和青少年神经行为缺陷的环境和营养原因的识别、预防和治疗孩子们; 2) 证明进行前瞻性流行病学研究以评估母体/胎儿次优碘水平和农药暴露对甲状腺激素水平和新生儿神经行为发育的影响的可行性。 作为我们能力建设工作的一部分，我们将在玛希隆公共卫生学院建立一个工作环境和人类发展营养联合研究中心，以促进研究人员和学生的交流与合作。我们的试点研究项目将从 3 个省的省级医院招募 108 名孕妇。他们将被要求提供有关营养、农药暴露和其他潜在混杂因素的信息。妇女将提供尿液和血液样本，并在出生时收集胎盘脐带血样本。将分析样品中的碘、农药和甲状腺激素水平。新生儿将接受 BNBAS 的神经行为测试。当婴儿返回进行 3-4 个月的常规免疫接种时，将使用 EEG/ERP 测试电池进行神经行为测试。将从母亲那里收集母乳进行农药和碘测量。我们的目标是利用这项试点研究启动一项前瞻性研究，研究碘不足、农药暴露以及其他潜在的营养和环境影响对泰国儿童神经发育的影响。此外，这项研究的长期目标是与泰国卫生部合作，制定和测试针对产前护理环境的预防计划。 公共健康相关性：检查环境条件（碘供应和农药暴露）对甲状腺和随后胎儿发育的作用不仅具有科学意义，而且还可能对公共健康产生重要的政策影响。发展中国家可用于解决广泛的公共卫生问题（包括 IID 和农药危害）的资源有限。更好地了解农药接触和碘缺乏相互作用的不利影响将使医生、个人和政府公共卫生官员和监管机构做出更明智的决定。

项目成果

A pilot study of maternal exposure to organophosphate pesticides and newborn neurodevelopment in Thailand.

泰国母亲接触有机磷农药和新生儿神经发育的初步研究。

• 发表时间: 2017-07
• 作者: Woskie, Susan;Kongtip, Pornpimol;Thanasanpaiboon, Wiroj;Kiatdamrong, Napaporn;Charoonrungsirikul, Nantha;Nankongnab, Noppanun;Surach, Anu;Phamonphon, Akkarat
• 通讯作者: Phamonphon, Akkarat

Organophosphate urinary metabolite levels during pregnancy, delivery and postpartum in women living in agricultural areas in Thailand.

泰国农业区妇女怀孕、分娩和产后的有机磷尿代谢水平。

• 发表时间: 2014
• 影响因子: 3
• 作者: Kongtip, Pornpimol;Nankongnab, Noppanun;Woskie, Susan;Phamonphon, Akkarat;Tharnpoophasiam, Prapin;Wilaiwan, Kitsiluck;Srasom, Punnee
• 通讯作者: Srasom, Punnee

The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment.

产前有机磷农药暴露对泰国婴儿神经发育的影响。

• 发表时间: 2017-05-27
• 作者: Kongtip, Pornpimol;Techasaensiri, Benyachalee;Nankongnab, Noppanun;Adams, Jane;Phamonphon, Akkarat;Surach, Anu;Sangprasert, Supha;Thongsuksai, Aree;Srikumpol, Prayoon;Woskie, Susan
• 通讯作者: Woskie, Susan