Affective Neuroscience of Schizophrenia and Bipolar Disorder

精神分裂症和双相情感障碍的情感神经科学

基本信息

批准号：
8114243
负责人：
WILLIAM P. HORAN
金额：
$ 17.51万
依托单位：
BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8114243
关键词：
Affective Anhedonia Applications Grants Arousal Auditory Benchmarking Biological Markers Bipolar Disorder Blinking Classification Clinical Communities Cues Diagnosis Diagnostic Discrimination Disease Emotional Emotional Disturbance Emotions Event-Related Potentials Funding Goals Impairment Incentives Individual Differences Measures Mental disorders Methods Moods National Institute of Mental Health Neurosciences Research Outcome Outpatients Patient Self-Report Patients Pattern Peripheral Peripheral Nervous System Physiological Process Psychotic Disorders Punishment Reaction Time Recording of previous events Recruitment Activity Research Resistance Rewards Schizophrenia Signal Transduction Stimulus Symptoms System Testing affective neuroscience attenuation base clinical phenotype comparison group disability emotional stimulus endophenotype expectation indexing novel pleasure psychosocial research study response severe mental illness therapy development trait

项目摘要

DESCRIPTION (provided by applicant): Schizophrenia (SCZ) and bipolar disorder-I (BPD) have many similarities, but they have notably different emotional response profiles to appetitive stimuli, and these are present even among clinically stable patients. The goal of this R21 application is to apply current affective neuroscience methods to understand the underlying processes for these different emotional response profiles. We will test hypotheses that stable outpatients with SCZ and euthymic BPD-I patients with a history of psychosis will demonstrate opposite central and peripheral nervous system responses to rewarding stimuli during two types of tasks: affective chronometry, which refers to the temporal parameters (e.g., anticipation, offset) of emotional responding, and motivational engagement, which refers to mobilization of physiological response systems during impending rewards and punishments. 35 SCZ outpatients, 35 euthymic BPD outpatients, and 35 matched healthy controls will complete the two types of paradigms while simultaneous ERP and startle eye blink responses are recorded. Affective chronometry will be measured with a passive emotional picture viewing task with startle probes before, during, and after picture presentation. Motivational engagement will be measured with an active motivational gradient task, in which cues signaling reward or punishment appear to loom progressively closer to the viewer. We predict SCZ patients will demonstrate hypo-reactivity and BPD patients will show hyper-reactivity for specific physiological responses to positive stimuli. Identification of emotional disturbances that are uniquely associated with SCZ and BPD would have direct implications for treatment development and identification of novel endophenotypes. PUBLIC HEALTH RELEVANCE: Schizophrenia (SCZ) and bipolar disorder-I (BPD) are two of the most severely disabling psychiatric disorders, and recent evidence suggests that notably different emotional response abnormalities contribute to poor outcome within each disorder. The goal of this R21 exploratory grant application is to apply affective neuroscience methods to test the hypothesis that stable outpatients with SCZ or BPD-I with a history of psychosis (in a euthymic mood state) will demonstrate differential central and peripheral nervous system responses during tasks that index affective chronometry and motivational engagement. Identification of emotional disturbances that are uniquely associated with each disorder would have direct implications for treatment development and novel emotional endophenotypes.

描述（由申请人提供）：精神分裂症（SCZ）和双相情感障碍-I（BPD）有许多相似之处，但它们对食欲刺激的情绪反应特征明显不同，甚至在临床稳定的患者中也存在这些情况。此 R21 应用程序的目标是应用当前的情感神经科学方法来了解这些不同情绪反应概况的基本过程。我们将测试这样的假设：稳定的 SCZ 门诊患者和有精神病史的情绪正常的 BPD-I 患者在两种类型的任务中将表现出相反的中枢和周围神经系统对奖励刺激的反应：情感计时，指的是时间参数（例如，情绪反应和动机参与，指的是在即将到来的奖励和惩罚期间调动生理反应系统。 35 名 SCZ 门诊患者、35 名正常 BPD 门诊患者和 35 名匹配的健康对照将完成两种类型的范例，同时记录 ERP 和惊恐眨眼反应。情感计时将通过在图片呈现之前、期间和之后使用惊吓探针进行被动情感图片观看任务来测量。动机参与度将通过主动动机梯度任务来衡量，其中表示奖励或惩罚的线索似乎逐渐接近观众。我们预测 SCZ 患者将表现出低反应性，而 BPD 患者将对积极刺激的特定生理反应表现出高反应性。识别与 SCZ 和 BPD 独特相关的情绪障碍将对治疗开发和新内表型的识别产生直接影响。公共卫生相关性：精神分裂症 (SCZ) 和双相情感障碍 (BPD) 是两种最严重的致残性精神疾病，最近的证据表明，明显不同的情绪反应异常会导致每种疾病的不良预后。这项 R21 探索性拨款申请的目标是应用情感神经科学方法来检验以下假设：具有精神病史（处于正常情绪状态）的稳定的 SCZ 或 BPD-I 门诊患者在任务期间会表现出不同的中枢和周围神经系统反应该指标反映了情感计时和动机参与。识别与每种疾病独特相关的情绪障碍将对治疗的发展和新的情绪内表型产生直接影响。