Sociocultural Factors and BRCA Genetic Counseling for Diverse Latinas

针对不同拉丁裔的社会文化因素和 BRCA 遗传咨询

基本信息

批准号：
8034828
负责人：
Lina Jandorf
金额：
$ 8.22万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-01 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8034828
关键词：
Acculturation Address Advisory Committees Area Attitude BRCA1 gene Belief Breast Cancer Etiology Cancer-Predisposing Gene Caring Cessation of life Counseling Decision Making Development Ensure Ethnic group Family Family history of Fees Focus Groups Future Genetic Genetic Counseling Genetic screening method Goals Healthcare High Risk Woman Individual Inherited Interview Latina Life Malignant Neoplasms Malignant neoplasm of ovary Medical Modeling Nature New York New York City Perception Population Population Group Predisposition Preventive Process Professional counselor Qualitative Methods Recording of previous events Research Risk Risk Management Services Slide Social support Socioeconomic Status Source Staging Stress Telephone Testing Woman base behavior prediction cancer diagnosis cancer risk design empowered experience flyer health disparity high risk intervention program malignant breast neoplasm prevent programs public health relevance social uptake

项目摘要

DESCRIPTION (provided by applicant): Project Summary Given the mounting evidence that hereditary breast and/or ovarian cancer (HBOC) substantially increases cancer risk in some families (1;2), it is critical that such high-risk women receive genetic counseling to empower them with life-saving information. Unfortunately, research suggests that Latinas, the fastest growing segment of the U.S. population, are the least likely of all ethnic groups to seek genetic counseling and subsequent testing for HBOC (3-5). The proposed exploratory qualitative R03 seeks to determine factors that explain the under-representation of Latinas in seeking BRCA genetic counseling for HBOC among high-risk women who have not previously undergone counseling. Guided by our Adapted Integrative Model of Behavioral Prediction (Figure 1), the specific aims are to explore and document: 1) Beliefs and attitudes about BRCA genetic counseling among diverse, high-risk Latinas with family histories suggestive of HBOC in New York City (NYC); 2) Sociocultural factors and their influence on beliefs and attitudes about BRCA genetic counseling among diverse, high-risk Latinas including: a) cultural beliefs and values; b) acculturation and acculturative stress; c) social support; d) personal and family history of breast and/or ovarian cancer; and e) organizational factors, including socioeconomic status and access to medical care. This information will help guide the future development of culturally-appropriate intervention programs to increase Latinas' participation in genetic counseling for breast and/or ovarian cancer susceptibility. PUBLIC HEALTH RELEVANCE: Project Narrative The proposed exploratory research will determine factors that explain the under-representation of Latinas in genetic counseling for hereditary breast and/or ovarian cancer (HBOC). This qualitative information will help guide the future development of culturally-appropriate intervention programs to increase Latinas' participation in BRCA genetic counseling for breast and/or ovarian cancer susceptibility and therefore seek to reduce the health disparity witnessed in this population group.

描述（由申请人提供）：项目摘要鉴于越来越多的证据表明遗传性乳腺癌和/或卵巢癌 (HBOC) 会显着增加某些家庭的癌症风险 (1;2)，因此此类高风险女性接受遗传咨询至关重要向他们提供拯救生命的信息。不幸的是，研究表明，拉丁裔美国人是美国人口增长最快的群体，他们是所有族裔群体中寻求遗传咨询和后续 HBOC 检测的可能性最小的 (3-5)。拟议的探索性定性 R03 旨在确定在以前未接受过咨询的高危女性中，拉丁裔在寻求针对 HBOC 的 BRCA 遗传咨询时代表性不足的因素。在我们的行为预测综合模型（图 1）的指导下，具体目标是探索和记录：1) 纽约市具有 HBOC 家族史的多元化高风险拉丁裔人群对 BRCA 遗传咨询的信念和态度（纽约）； 2) 社会文化因素及其对多元化、高风险拉丁裔人群中关于 BRCA 遗传咨询的信念和态度的影响，包括： a) 文化信念和价值观； b) 文化适应和文化适应压力； c) 社会支持； d) 乳腺癌和/或卵巢癌的个人史和家族史； e) 组织因素，包括社会经济地位和获得医疗保健的机会。这些信息将有助于指导未来制定适合文化的干预计划，以增加拉丁裔美国人对乳腺癌和/或卵巢癌易感性遗传咨询的参与。公共卫生相关性：项目叙述拟议的探索性研究将确定解释拉丁裔在遗传性乳腺癌和/或卵巢癌 (HBOC) 遗传咨询中代表性不足的因素。这些定性信息将有助于指导未来制定适合文化的干预计划，以增加拉丁美洲人对乳腺癌和/或卵巢癌易感性的 BRCA 遗传咨询的参与，从而寻求减少该人群中出现的健康差距。