Finding effective treatments for inhaled chlorine-induced injury related pain

寻找吸入氯引起的损伤相关疼痛的有效治疗方法

基本信息

批准号：
8416168
负责人：
Sadis Matalon
金额：
$ 36.63万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-28 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8416168
关键词：
Accidents Adrenergic Agonists Adrenergic Receptor Adrenergic beta-Agonists Adverse effects Affect Agonist Anesthetics Anti-Inflammatory Agents Anti-inflammatory Antidotes Behavioral Biochemical Biochemical Markers Breathing Bronchial Spasm Bronchoalveolar Lavage Cardiovascular system Caring Cessation of life Chemical Warfare Chest Pain Chlorine Clinical Clinical Treatment Controlled Clinical Trials Coronary Arteriosclerosis Coughing Coupled Data Devices Dyspnea Equipment Evaluation Event Exposure to Functional disorder Gases Hand Hospitals Hypoxia Individual Industrial Accidents Inflammation Injury Irritants Laboratories Lidocaine Literature Local Anesthetics Locomotion Lung Measurement Measures Medical Methodology Modeling Morbidity - disease rate Movement Mus Nebulizer Neurologic Nose Opioid Oral cavity Oxygen saturation measurement Pain Pharmaceutical Preparations Poisoning Pump Regimen Respiration Respiratory Failure Respiratory physiology Sampling Sensory Serum Stridor Structure Structure of parenchyma of lung Symptoms System Terrorism Testing Tissues Toxic effect Translating Transportation Vent World War I base cardiopulmonary system clinical practice effective therapy improved irritation lung injury men mortality novel therapeutic intervention pain behavior planetary Atmosphere respiratory response treatment effect

项目摘要

DESCRIPTION (provided by applicant): Chlorine (Cl2) is a highly irritant and reactive gas produced in large quantities throughout the world. Exposure to Cl2 released into the atmosphere during transportation and industrial accidents, as well as acts of terrorism, has resulted in significant lung injury leading to death from respiratory failure or significant morbidty. Our recent data show that there may be benefit to treating subjects exposed to Cl2 with inhaled local anesthetics. The present studies will examine the effects of this treatment as monotherapy or in combination with a beta adrenergic agonist on measures of pain and inflammation in murine models. PUBLIC HEALTH RELEVANCE: We will assess whether inhaled local anesthetics alone and as an adjunct to beta adrenoceptor agonist, will be effective in reducing pain behaviors and in reducing morbidity and mortality following Cl2 exposure in mice.

描述（由申请人提供）：氯（CL2）是全世界大量产生的高度刺激性和反应性气体。在运输和工业事故中释放到大气中的CL2以及恐怖主义行为，导致肺部重大损伤导致呼吸道衰竭或严重的病态导致死亡。我们最近的数据表明，使用吸入局部麻醉药接触到CL2的受试者可能会有好处。本研究将研究这种治疗作为单一疗法的影响，或与β肾上腺素能激动剂结合使用鼠模型中疼痛和炎症的测量。公共卫生相关性：我们将评估单独吸入的局部麻醉剂和作为Beta adrenoceptor激动剂的辅助功能，将有效地减少疼痛行为，并降低小鼠CL2暴露后的发病率和死亡率。