Minority Health-GRID Network: A Genomics Resource for Health Disparity Research

少数民族健康网格网络：健康差异研究的基因组学资源

• 批准号: 8048812
• 负责人: ROBERT Lowell DAVIS
• 金额: $ 1332万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2013-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8048812
• 关键词: Abbreviations; Academic Medical Centers; Address; Admixture; Affect; African American; Architecture; Area; Beds; Behavioral; Behavioral Genetics; Bioethics; Bioinformatics; Caring; Cataloging; Catalogs; Characteristics; Chronic Kidney Failure; Clinic; Clinical; Clinical Data; Clinical Research; Clinical assessments; Collection; Communities; DNA; Data; Data Element; Data Set; Databases; Diabetes Mellitus; Diet; Disease; Electronic Health Record; Elements; Ensure; Environmental Risk Factor; Essential Hypertension; Etiology; Foundations; Frequencies; Genetic; Genetic Determinism; Genetic Markers; Genome; Genomics; Genotype; Health; Health Status; Hypertension; Institutes; Institution; Internet; Kidney Diseases; Kidney Failure; Knowledge; Learning; Link; Malignant neoplasm of prostate; Medical; Medicine; Minority; Minority Groups; Modeling; Myocardial Infarction; Obesity; Outcome; Outcomes Research; Patients; Phenotype; Physical activity; Plague; Population; Population Surveillance; Positioning Attribute; Public Health; Race; Recording of previous events; Research; Research Infrastructure; Resolution; Resources; Science; Scientist; Severities; Southeastern United States; Stroke; Structure; System; Technology; Testing; Translational Research; Translations; Trust; Underrepresented Minority; United States National Institutes of Health; Variant; abstracting; base; burden of illness; cohort; comparative effectiveness; computerized; data modeling; defined contribution; design; disease registry; early onset; effectiveness research; exome; genome-wide; health disparity; health literacy; improved; innovation; insight; medical schools; medically underserved; minority health; novel; premature; programs; public health relevance; racial and ethnic; racial/ethnic difference; repository; safety net; social; tool; virtual

DESCRIPTION (provided by applicant): The persistence of health disparities in medically underserved minority communities remains one of the most vexing public health problems facing our nation; the etiology of racial/ethnic differences in health involves dynamic interactions between genetic, behavioral and social-environmental determinants. Yet the field lacks robust, longitudinal datasets that integrate these multi-dimensional data elements with clinical assessments in minority patient cohorts. The Minority Health Genomics and Translational Research BIo-Repository Database (MH-GRID) Network infrastructure will facilitate the ascertainment of biospecimens, the collection of multi- dimensional data elements and the tracking of patient outcomes in an electronic health records (EHRs)-linked data warehouse within a consortium of minority clinics. This initiative will expand the diversity of bio-ancestral groups in national genomic medicine cohorts, provide a platform for 'virtual' disease registries catalyze comparative effectiveness research in high-health disparity settings and accelerate the translation of 'personalized medicine' into minority communities. This project will fulfill the objectives of the NIH Director's priority areas (RFA-OD-10-005) and the ARRA by pursuing the following specific aims: Aim I: To establish an organizational framework for the Minority Health-GRID Network as a consortium of academic medical centers and minority-serving 'safety-net' medical care facilities. Aim II: To establish an electronic health record (EHR)-linked bioinformatics/bio-repository infrastructure that facilitates in-depth genotyping, phenotypic characterization and longitudinal surveillance of minority patients. Aim III: To demonstrate the unique utility of the MH-GRID resource with a 'use-case' project that defines the genetic, personal and social-environmental determinants of severe hypertension (HTN) in African-Americans. The fulfillment of these specific aims will enable the MH-GRID to establish the largest genomic medicine database devoted to minority patients. A major objective of the MH-GRID is to utilize high-throughput sequencing technology to create a genome-wide catalogue of the 'Exome' in 2400 African-Americans (AA). Overall, this project provides a 'grand opportunity' to establish a novel national research resource that will advance genomic science while addressing a variety of health disparity conditions that currently plague under- served minority communities. PUBLIC HEALTH RELEVANCE: High blood pressure is a very common problem that is a major cause of heart attacks, strokes and kidney failure. It affects African-Americans much more commonly than other racial groups. There are many diseases like high blood pressure that are more common in certain racial/ethnic and there is a need to improve the use of computerized systems in clinics that care for a high proportion of minority patients so that their health status can be improved. In addition, there is much that we have to learn about genetic differences between different minority groups that may contribute to these differences in health. The proposed project will be a major innovation to fill this knowledge gap in the areas of genetics and health disparities.

描述（由申请人提供）：医疗服务不足的少数族裔社区持续存在的健康差距仍然是我们国家面临的最棘手的公共卫生问题之一；种族/族裔健康差异的病因涉及遗传、行为和社会环境决定因素之间的动态相互作用。然而，该领域缺乏强大的纵向数据集，无法将这些多维数据元素与少数患者群体的临床评估相结合。少数族裔健康基因组学和转化研究生物存储数据库 (MH-GRID) 网络基础设施将促进生物样本的确定、多维数据元素的收集以及电子健康记录 (EHR) 关联数据中患者结果的跟踪少数族裔诊所联盟内的仓库。该举措将扩大国家基因组医学队列中生物祖先群体的多样性，为“虚拟”疾病登记提供平台，促进高健康差距环境中的比较有效性研究，并加速“个性化医疗”向少数群体社区的转化。该项目将通过追求以下具体目标来实现 NIH 主任优先领域 (RFA-OD-10-005) 和 ARRA 的目标： 目标 I：为少数民族健康网格网络建立一个组织框架，作为一个联盟学术医疗中心和为少数族裔服务的“安全网”医疗保健设施。目标二：建立与电子健康记录（EHR）相关的生物信息学/生物存储库基础设施，以促进对少数族裔患者的深入基因分型、表型表征和纵向监测。目标 III：通过“用例”项目展示 MH-GRID 资源的独特效用，该项目定义了非裔美国人严重高血压 (HTN) 的遗传、个人和社会环境决定因素。 这些具体目标的实现将使 MH-GRID 能够建立专门针对少数族裔患者的最大的基因组医学数据库。 MH-GRID 的一个主要目标是利用高通量测序技术创建 2400 名非裔美国人 (AA) 的“外显子组”全基因组目录。总体而言，该项目提供了一个建立新颖的国家研究资源的“绝佳机会”，该资源将推动基因组科学的发展，同时解决目前困扰服务不足的少数族裔社区的各种健康差距问题。 公众健康相关性：高血压是一个非常常见的问题，是心脏病发作、中风和肾衰竭的主要原因。它对非裔美国人的影响比其他种族群体更常见。有许多疾病，例如高血压，在某些种族/族裔中更为常见，需要改进在照顾高比例少数族裔患者的诊所中计算机化系统的使用，以便改善他们的健康状况。此外，我们还需要了解很多不同少数群体之间的遗传差异，这些差异可能导致这些健康差异。拟议的项目将是一项重大创新，旨在填补遗传学和健康差异领域的知识空白。

项目成果

Machine Learning Data Imputation and Classification in a Multicohort Hypertension Clinical Study.

多队列高血压临床研究中的机器学习数据插补和分类。

• 发表时间: 2015
• 作者: Seffens, William;Evans, Chad;Minority Health;Taylor, Herman
• 通讯作者: Taylor, Herman

Study designs and methods post genome-wide association studies.

全基因组关联研究后的研究设计和方法。

• 发表时间: 2012-10
• 影响因子: 5.3
• 作者: Ziegler, Andreas;Sun, Yan V
• 通讯作者: Sun, Yan V

Perceived neighborhood problems are associated with shorter telomere length in African American women.

非洲裔美国女性的端粒长度较短与社区问题有关。

• 发表时间: 2016
• 影响因子: 3.7
• 作者: Gebreab, Samson Y;Riestra, Pia;Gaye, Amadou;Khan, Rumana J;Xu, Ruihua;Davis, Adam R;Quarells, Rakale C;Davis, Sharon K;Gibbons, Gary H
• 通讯作者: Gibbons, Gary H

SimRare: a program to generate and analyze sequence-based data for association studies of quantitative and qualitative traits.

SimRare：一个生成和分析基于序列的数据的程序，用于定量和定性特征的关联研究。

• 发表时间: 2012-10-15
• 作者: Li, Biao;Wang, Gao;Leal, Suzanne M
• 通讯作者: Leal, Suzanne M

Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH-GRID Study.

Apelin、Visfatin 和尿 8-异前列烷与非裔美国人严重高血压的关联：MH-GRID 研究。

• DOI: 10.1093/ajh/hpw007
• 发表时间: 2016-07-01
• 期刊: American journal of hypertension
• 影响因子: 3.2
• 作者: Steven R Horbal;W. Seffens;Adam R. Davis;Natalia A. Silvestrov;G. Gibbons;Rakale Quarells;A. Bidulescu
• 通讯作者: A. Bidulescu