Perfluoroalkyl chemicals and the risk of developing clinical and subclinical CVD

全氟烷基化学品和发生临床和亚临床 CVD 的风险

• 批准号: 8365439
• 负责人: Anoop Shankar
• 金额: $ 39.41万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365439
• 关键词: Abdomen; Acetic Acids; Acids; Address; Adult; Alcohol consumption; Alkanesulfonates; American; Ancillary Study; Animals; Ankle; Asian Americans; Atherosclerosis; Behavior; Blood; Blood Pressure; Body mass index; C-reactive protein; Calcium; Cardiovascular Diseases; Carpet; Chemical Exposure; Chemicals; Chinese People; Chronic Kidney Failure; Clinical; Cohort Studies; Control Groups; Coronary; Coronary artery; Coronary heart disease; Cross-Sectional Studies; Data; Disease; Environment; Ethnic Origin; Ethnic group; Exposure to; Filtration; Fire - disasters; Food; Funding; Future; Gender; General Population; Health; Hispanics; Household; Human; Laboratories; Left; Left Ventricular Mass; Licensing; Lipids; Literature; Longitudinal Studies; Lubricants; Measures; Medial; Microalbuminuria; National Heart, Lung, and Blood Institute; Outcome; Outcome Study; Paper; Parents; Participant; Physical Examination; Play; Polishes; Procedures; Prospective Studies; Public Health; Questionnaires; Race; Research Design; Resources; Risk; Role; Sampling; Serum; Smoking; Societies; Stroke; Sulfonamides; Surveys; Text; Textiles; Thick; United States; United States National Institutes of Health; Ventricular; Visit; Woman; cardiovascular disorder risk; cohort; cost effective; design; fasting glucose; follow-up; glomerular basement membrane; indexing; men; perfluorodecanoic acid; perfluorohexane; perfluorooctane; perfluorooctane sulfonate; population based; post gamma-globulins; prevent; prospective; racial and ethnic; racial/ethnic difference; surfactant

DESCRIPTION (provided by applicant): The overall aim of this proposal is to study the prospective association between serum levels of PFCs and the risk of developing coronary heart disease (CHD), stroke, cardiovascular disease (CVD), subclinical measures of atherosclerosis and hypertensive left ventricular changes among the participants of the of the Multi-ethnic Study of Atherosclerosis (MESA), a large, multiethnic, population-based, longitudinal cohort study with participants representing both men and women and the various racial/ethnic groups in the US, including whites, blacks, Hispanics, and Asian Americans and with up to 10 years of follow-up data. We will also evaluate gender and racial/ethnic differences in PFC exposure among Americans in this contemporary general population sample and examine if the association between PFCs and CVD vary by gender, or race/ethnicity. Ours is an ancillary study that builds upon the existing strengths and resources of the NIH-funded, parent MESA cohort study to address our multiple study aims in an efficient and cost-effective manner. In the MESA, we already have data on 1) the main study outcomes, including incident CHD, stroke, and CVD validated following standard criteria and procedures adapted from other successful studies such as the NHLBI-funded ARIC study, subclinical measures of atherosclerosis including coronary artery calcium (CAC), abdominal aortic calcium (AAC), carotid intimal-medial thickness (CIMT), low ankle-brachial index (ABI), and hypertensive left ventricular parameters including left ventricular mass, volume and mass to volume (M/V) ratio 2) detailed questionnaire, physical examination, and laboratory data on potential confounding factors such as smoking, alcohol intake, body mass index (BMI), blood pressure, fasting glucose, serum lipids, high sensitivity C-reactive protein, and several other markers. In the current study, we propose a case-cohort study nested within the MESA cohort to newly measure serum levels of perfluorooctanoic acid (PFOS), perfluorooctane sulfonate (PFOA), perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), and 7 other commonly detected PFCs, including perfluoroheptanoic acid (PFHpA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnA), perfluorododecanoic acid (PFDoA), perflurooctane sulfanomide (PFOSA), 2-(N-ethyl-perflurooctane sulfonamido) acetic acid (Et-PFOSA-AcOH), and 2-(N-methyl-perflurooctane sulfonamide) acetic acid (Me- PFOSA-AcOH), in the baseline serum of all incident CHD (n=523), and stroke (n=224), cases and a race- stratified cohort random sample of n=1000 participants (35% white, 28% black, 22% Hispanic and 12% Chinese). This study design will allow us to examine the longitudinal associations between baseline serum PFC levels and multiple outcomes using the same "control" group as well as to make valid cross-sectional comparisons (e.g. serum PFC levels by race-ethnicity). Our study is significant because it addresses a critical barrier in the field: the lack of longitudinal studies examining the relationship between PFC exposure and the risk of clinical and subclinical measures of CVD. PUBLIC HEALTH RELEVANCE: Perfluroalkyl chemicals (PFC) are detectable in the blood of >98% of US adults. We will study the association between blood PFCs and cardiovascular disease. If we find an association, it indirectly suggests that reducing PFCs may have a role in preventing these diseases.

描述（由申请人提供）：该提案的总体目的是研究PFC的血清水平与发展冠心病（CHD）（CHD），中风，心血管疾病（CVD）的前瞻性关联多民族研究的动脉粥样硬化研究（MESA）的参与者之间的左心室变化，这是一项大型，多种族的基于人群的，纵向同伴的研究，参与者代表男人和女性，以及美国各种种族/族裔群体，在美国，包括白人，黑人，西班牙裔和亚裔美国人，以及多达10年的后续数据。我们还将评估这个当代普通人群样本中美国人PFC暴露的性别和种族/种族差异，并检查PFC和CVD之间的关联是否因性别而异，还是种族/种族。我们的是一项辅助研究，基于NIH资助的父母Mesa队列研究的现有优势和资源，旨在以有效且具有成本效益的方式解决我们的多项研究目标。在MESA中，我们已经有关于1）主要研究结果的数据，包括事件冠心病，中风和CVD，遵循标准标准验证的标准标准和从其他成功研究的程序进行了验证，例如NHLBI资助的ARIC研究，包括冠心病的亚临床测量动脉钙（CAC），腹主动脉钙（AAC），颈动脉内膜厚度（CIMT），低脚踝 - 支撑指数（ABI）和高血压左心室参数，包括左心室质量，体积和体积（M/V） ）比率2）详细的问卷，体格检查和实验室数据，涉及吸烟，酒精摄入，体重指数（BMI），血压，空腹葡萄糖，血清脂质，高灵敏度C-反应蛋白以及其他几种其他几种可能的混杂因素数据标记。在当前的研究中，我们提出了一项嵌套在梅萨队列中的病例研究研究，以新测量全氟辛酸的血清水平（PFOS），全氟辛烷磺酸盐（PFOA），全氟己烷磺酸盐（PFHXS）（PFHXS），荧光酮（PFHXS），pluoronananoicic酸（PFHXS），PFRNNA）和77）和77）和7个。通常检测到的PFC，包括全氟乙酸（PFHPA），全氟二烷酸（PFDA），pluoroundecanoic酸（PFUNA），pluorodododecanoic酸，PFDOA（PFDOA） - PFOSA-ACOH）和2-（N-甲基 - 透明质酸磺胺磺酰胺）乙酸（Me- Pfosa-Acoh），在所有入射CHD的基线血清中n = 1000名参与者的种族分层队列样本（35％白色，黑色28％，22％西班牙裔和12％中文）。这项研究设计将使我们能够使用相同的“控制”组以及进行有效的横截面比较（例如，按种族种族划分的血清PFC水平）检查基线血清PFC水平与多个结果之间的纵向关联。我们的研究很重要，因为它解决了该领域的关键障碍：缺乏研究PFC暴露与CVD临床和亚临床测量风险之间关系的纵向研究。 公共卫生相关性：> 98％的美国成年人的血液中可检测到全氟烷基化学物质（PFC）。我们将研究血液PFC与心血管疾病之间的关联。如果我们找到了关联，则间接表明减少PFC可能在预防这些疾病中起作用。