Clinical Samples

临床样本

• 批准号: 8376053
• 负责人: JOSEPH Wayne FAY
• 金额: $ 14.23万
• 依托单位: BAYLOR RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8376053
• 关键词: Cataloging; Catalogs; Cells; Clinical; Clinical Data; Collaborations; Collection; Correlative Study; Data; Data Analyses; Data Collection; Ensure; Fostering; Future; Goals; Grant; Histocompatibility Testing; Human; Immune; Immune response; Immunization; Instruction; Laboratories; Lead; Location; Mission; Molecular Profiling; Names; Nomenclature; Process; Research Infrastructure; Research Personnel; Resources; Sampling; Scheme; Secure; Serum; Site; Specimen; Structure; System; Systems Analysis; Technology; Vaccines; Work; cost effective; data integration; data management; programs; repository; response; sample collection; sound

The proposed analysis of immune responses generated after immunization in this project entitled, "Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans", will take advantage of a collection of technologies on a variety of sample types. Indeed, the cumulative efforts from this project will generate an invaluable set of samples as a resource both for the proposed studies and future experimental questions. Thus, the necessary and important mission ofthe Clinical Sample Core is to insure that all specimens, clinical information that is generated by each of the projects will be systematically catalogued and tracked, adequately stored, and appropriately disseminated. The Clinical Sample Core will take advantage ofthe well-established infrastructure and successful collaboration between the investigators at BIIR and other participating sites. By consolidating the receipt, handling, and distribution of all samples from this U19 into one unified structure, the Clinical Sample Core will provide high quality clinical samples for the various analyses and immune studies proposed across all of the projects in the Center. The proposed infrastructure will optimize the use of samples and resources among the different investigators, providing the necessary synergy and integration in an efficient and cost-effective manner. Summarily, the Clinical Sample Core will allow us to carry out studies that we consider essential for achieving the overall goals of the Center by accomplishing the following significant objectives: 1) guarantee the integrity of incoming samples; 2) ensure the quality and consistency of the clinical data associated with the samples; 3) enforce a common sample ID nomenclature for all collection sites it which in turn will facilitate data integration and analysis within and across projects; 4) work with the broader data management scheme at BIIR that will help assure that the data generated in this project will be available for re-analysis in future projects.

该项目中免疫后产生的免疫反应的拟议分析，标题为“系统” 对健康和反应性人类中的疫苗反应分析”将利用收集 各种样本类型的技术。确实，该项目的累积努力将产生 无价的样品集作为拟议的研究和未来实验问题的资源。 因此，临床样本核心的必要和重要任务是确保所有标本，即 每个项目生成的临床信息将被系统地分类和跟踪， 充分存储并适当传播。临床样本核心将利用 BIIR与其他调查人员与其他研究人员与其他建立的基础设施和成功的合作 参与网站。 通过将所有样品从该U19的收据，处理和分布合并为一个统一结构， 临床样品核心将为各种分析提供高质量的临床样本和免疫 研究中心的所有项目都提出了研究。拟议的基础架构将优化 不同研究人员之间的样本和资源，提供必要的协同和整合 一种有效且具有成本效益的方式。总而言之，临床样本核心将使我们能够进行研究 我们认为通过完成以下内容来实现中心的整体目标至关重要 重要目标：1）保证传入样本的完整性； 2）确保质量和一致性 与样品相关的临床数据； 3）执行所有人的常见样本ID命名法 收集站点又将促进项目内部和跨项目内的数据集成和分析； 4）工作 借助BIIR的更广泛的数据管理方案，它将有助于确保在此生成的数据 项目将用于未来项目的重新分析。