CLINICAL INFORMATICS

临床信息学

• 批准号: 7944788
• 负责人: LELAND H HARTWELL
• 金额: $ 30.24万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-10 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944788
• 关键词: Accountability; Cancer Center Support Grant; Chest; Clinical; Clinical Data; Clinical Research; Data; Data Collection; Databases; Development; Disease; Environment; Feeds; Fred Hutchinson Cancer Research Center; Future; Gastroenterology; Gynecology; Housing; Informatics; Long-Term Effects; Lung; Malignant neoplasm of prostate; Online Systems; Patients; Population; Prostate; Quality of life; Research; Research Infrastructure; Resource Sharing; Solid Neoplasm; Survivors; System; Transplantation; abstracting; base; data integration; design; human subject protection; malignant breast neoplasm; member; oncology; programs

The most important functions of the shared resource are to establish and maintain databases that enable access to clinical data for research purposes. The shared resource also supports other informatics efforts that enhance the ability of the Consortium to conduct clinical research in an environment increasingly sensitive to human subjects' protections and regulatory accountability. For 30 years, transplant data collection and distribution at Fred Hutchinson Cancer Research Center (FHCRC) has been a centralized activity, with a comprehensive database now of over 12,000 transplants performed at FHCRC that is used routinely by all Consortium members engaged in clinical transplant research. These data are housed in an Ingres database referred to as Gateway. Data from approximately 400 new transplants are added each year and over 3,000 patients are being followed as survivors of transplant. This provides a large database for characterizing the short- and long-term effects of transplant on survival and quality of life. The shared resource comprises dedicated data collection staff responsible for abstracting and entering data from the entire transplant treatment course and a Transplant Informatics Group (TIG) that develops and maintains the Gateway database. The Solid Tumor Informatics Group (STIG) was established in 2002 to develop and operate the computing infrastructure needed to support the solid tumor clinical research programs. Research databases are currently available for prostate and breast cancer subjects; future databases will include gastroenterology, gynecology, and lung/thoracic subjects. This group is responsible for the design, development, enhancement, implementation, and oversight of the Consortium Oncology Data Integration (CODI) data warehouse that aggregates clinical data for solid tumor research. Data enters the warehouse from automated data feeds and web-based data entry systems based on a system called Caisis. Although Caisis originated from an application specifically designed to support a prostate cancer database, it is adaptable to other disease populations. At present the prostate and breast cancer databases are populated with data from approximately 3,500 and more than 16,000 subjects, respectively.

共享资源最重要的功能是建立和维护数据库 能够出于研究目的访问临床数据。共享资源还支持其他 信息学工作增强了联盟开展临床研究的能力 环境对人类受试者的保护和监管责任越来越敏感。 Fred Hutchinson 癌症研究中心 30 年来收集和分发移植数据 (FHCRC) 一直是一项集中活动，目前拥有超过 12,000 个综合数据库 在 FHCRC 进行的移植是所有从事临床工作的联盟成员常规使用的 移植研究。这些数据存储在称为 Gateway 的 Ingres 数据库中。数据来自 每年新增约 400 例新移植手术，并且正在对 3,000 多名患者进行随访 移植的幸存者。这提供了一个大型数据库来描述短期和长期的特征 移植对生存和生活质量的影响。共享资源包括专用数据 采集人员负责提取和输入整个移植治疗过程中的数据 以及开发和维护网关数据库的移植信息学小组 (TIG)。 实体瘤信息学小组 (STIG) 成立于 2002 年，旨在开发和运营 支持实体瘤临床研究项目所需的计算基础设施。研究 目前有前列腺癌和乳腺癌受试者的数据库；未来的数据库将包括 胃肠病学、妇科和肺/胸科科目。这个小组负责设计， 联盟肿瘤学数据的开发、增强、实施和监督 集成 (CODI) 数据仓库，聚合实体瘤研究的临床数据。 数据从自动数据源和基于网络的数据输入系统进入仓库 基于名为 Caisis 的系统。尽管 Caisis 源自一个专门的应用程序 它旨在支持前列腺癌数据库，也适用于其他疾病人群。 目前，前列腺癌和乳腺癌数据库中的数据来自 分别有大约 3,500 名和超过 16,000 名受试者。