BIOMECHANICS CORE

生物力学核心

基本信息

批准号：
7802705
负责人：
JAMES Anthony ASHTON-MILLER
金额：
$ 12.84万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7802705
关键词：
Affect Age Aging American Area Biomechanics Centers for Disease Control and Prevention (U.S.)Characteristics Collaborations Computer Simulation Deterioration Diagnosis Diagnostic tests Discipline Elderly Equilibrium Exercise Faculty Female Fostering Functional disorder Funding Future Gait Goals Impairment Individual Injury Life Maintenance Measurement Mentorship Methods Mission Muscle Contraction Musculoskeletal Equilibrium Neurologic Patients Pelvic floor structure Phenotype Physiological Pilot Projects Prevention Prevention Protocols Process Protocols documentation Ptosis Published Comment Research Research Personnel Research Training Role Services Surface Syndrome Technical Expertise Technology Transfer Testing Training Urethra Urinary Incontinence aged bench to bedside career development data acquisition design disability effective therapy experience falls injury prevention insight interest motor control programs ranpirnase response sphincter ani muscle structure

项目摘要

Whatever the underlying physiologic or neurologic mechanisms, questions about loss of mobility, deterioration of motor control, responses to impending falls, maintenance of balance and postural control, changes in muscle contraction characteristics and maintenance of continence are ultimately biomechanical questions (Ashton-Miller & Alexander, 2003). The facilities of the Biomechanics Core will enable examination of such questions quantitatively, from the viewpoint of biomechanics and other physiological measurements. In particular the Biomechanics Core will contribute to the mission of the UM Pepper Center by fostering research Into the mechanisms by which certain predictor and modifying variables earlier in life may affect the expression of aged phenotypes. Applications of Biomechanics Research: There is ample justification for funding research and research training that help examine the role of biomechanical and other physiological mechanisms that contribute to the aged phenotypes as well as to physical impairments, syndromes and disability in elderfy people. The insights such research will provide apply to (1) designing diagnostic tests that can quantify precisely physical impairment in elderiy people, (2) designing more effective therapy programs for elderiy people who are already impaired, (3) designing protocols, such as exercise protocols, for prevention of physical impairments in elderiy people. Areas of particular interest include aging, gait on regular and irregular surfaces, mobility, fall-related injuries, as well as female pelvic floor function, urinary incontinence and prolapse, and (4) in transferring technology from bench to bedside. The latter goals are consistent with the CDC Injury Prevention Agenda 2009-2018 (National Center for Injury Prevention and Control, 2009).

无论潜在的生理或神经机制是什么，有关活动能力丧失、运动能力恶化的问题控制、对即将跌倒的反应、维持平衡和姿势控制、肌肉变化收缩特征和失禁的维持最终是生物力学问题（Ashton-Miller & Alexander，2003）。生物力学核心的设施将使这些问题能够从以下角度进行定量研究：生物力学和其他生理测量。特别是生物力学核心将有助于 UM Pepper 中心的使命是促进对某些机制的研究生命早期的预测变量和修改变量可能会影响老年表型的表达。生物力学研究的应用：资助研究和研究有充分的理由有助于检查生物力学和其他生理机制的作用的培训老年表型以及老年人的身体损伤、综合症和残疾。这此类研究将提供的见解适用于（1）设计可以精确量化的诊断测试老年人身体障碍，（2）为老年人设计更有效的治疗方案已经受损，（3）设计方案，例如运动方案，以预防身体损伤老年人的损伤。特别感兴趣的领域包括衰老、规则和不规则表面上的步态、活动能力、跌倒相关损伤以及女性盆底功能、尿失禁和脱垂，以及 (4) 将技术从实验室转移到床边。后者的目标与 CDC 伤害预防一致 2009-2018 年议程（国家伤害预防控制中心，2009 年）。