PILOT CORE

先导核心

• 批准号: 8128266
• 负责人: John H. Krystal
• 金额: $ 12.97万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8128266
• 关键词: Address; Advisory Committees; Alcohol dependence; Alcoholism; Alcohols; Area; Attention; Behavior; Biology; Biometry; Brain; Clinical; Collaborations; Conflict (Psychology); Consultations; Data; Development; Doctor of Medicine; Doctor of Philosophy; Dopamine; Electronic Mail; Electrophysiology (science); Evaluation; Event; Faculty; Feedback; Foundations; Functional Magnetic Resonance Imaging; Funding; Genetic; Grant; Habits; Human; Individual; Lead; Learning; Length; Life; Medicine; Mission; Neurosciences; Paper; Pilot Projects; Positron; Prevention strategy; Procedures; Process; Protocols documentation; Psychiatry; Publishing; Research; Research Personnel; Research Project Grants; Research Subjects; Review Committee; Risk; Technology; Testing; Therapeutic Agents; United States National Institutes of Health; Universities; Voting; Writing; alcohol testing; base; data management; innovation; meetings; member; neural circuit; neuroimaging; neuromechanism; novel; novel therapeutics; programs; radiotracer; response; translational neuroscience; treatment strategy; web page

The Pilot Projects Core provides a mechanism to provide a limited amount of funding to investigators to collect pilot data for innovative research projects. These projects serve the CTNA by 1) testing hypotheses or addressing methodologic issues central to the CTNA, 2) bringing new investigators into the CTNA and the field of alcoholism research, 3) generating new alcoholism RO1's, 4) enabling CTNA to rapidly adapt to advances in the field, and 5) guiding the next iteration of the CTNA. Pilot Project Proposals are solicited through an open and public solicitation process. Proposal are developed in collaboration with the CTNA Cores (Data Management and Biostatistics, Clinical, Genetics) and refined with feedback from the Executive Committee. The following four studies are proposed for the first two years of CTNA funding: 1) Dana Small, Ph.D. will lead the first human functional neuroimaging (fMRI) study to describe the neural circuitry underlying alcohol-related habit formation. 2) Philip Corlett, Ph.D. will initially conduct a behavior/electrophysiology study and then, building on this, conduct an fMRI study to explore neural mechanisms related to the impact of alcohol-related learning upon attention. 3) Anissa Abi-Dargham, M.D. will conduct the first evaluation of alterations in cortical dopamine release associated with alcohol dependence, using the new radiotracer [11C]FLB457 and positron emission tomorgraphy (PET). We also briefly describe additional outstanding proposals under consideration for the outlying years (3-5) of CTNA.

飞行员项目核心提供了一种机制，可以向研究人员提供有限资金，以收集用于创新研究项目的试点数据。这些项目通过1）测试假设或解决CTNA中心的方法论问题，2）将新的研究人员带入CTNA和酒精中毒研究领域，3）3）产生新的酒精中毒RO1，4）使CTNA能够迅速适应该领域的进步，以及5）指导CTNA的下一个迭代。试点项目建议是通过开放和公共招标过程征求的。提案是与CTNA核心（数据管理和生物统计学，临床，遗传学）合作开发的，并通过执行委员会的反馈进行了完善。在CTNA资金的前两年提出了以下四项研究： 1）Dana Small，博士将领导首次人类功能性神经影像学（fMRI）研究，以描述与酒精相关习惯形成的神经回路。 2）Philip Corlett博士最初将进行行为/电生理研究，然后在此基础上进行fMRI研究，以探索与酒精相关学习对注意力的影响有关的神经机制。 3）医学博士Anissa Abi-Dargham将使用新的放射性示意剂[11C] FLB457和正电子发射明星图（PET）对与酒精依赖性相关的皮质多巴胺释放的改变进行了首次评估。 我们还简要描述了CTNA偏远的年份（3-5）中正在考虑的其他出色建议。