CLINICAL CORE

临床核心

• 批准号: 8441025
• 负责人: LAWRENCE S HONIG
• 金额: $ 69.45万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441025
• 关键词: CLINICAL; CORE

The Clinical Core is the key resource ofthe ADRC. Principal goals are to: (1) enroll, evaluate, characterize, and follow elderly persons, non-demented, with mild cognitive impairment, or with Alzheimer's disease or other forms of dementia, from diverse ethnic backgrounds; (2) obtain and maintain high quality data on these subjects for the Center and for the National Alzheimer's Coordinating Center (NACC); (3) provide wellcharacterized patients for clinical trials and other allied research projects; and (4) operate an autopsy program to maximize utility and amount of material for the Neuropathology Core. Goals are to increase understanding ofthe etiologies of mild cognitive impairment and dementia among individuals of differing cultural, ethnic, and socioeconomic backgrounds, improve early detection; and sharpen the accuracy of the differential diagnosis of dementia. Subjects are recruited from the Columbia University memory centers operating at The Neurological Institute, New York State Psychiatric Institute, Harlem Hospital Satellite, and from volunteers and community-dwelling persons receiving healthcare from a nearby collaborating facility, Isabella Geriatric Center. The Clinical Core recruits a sample including about 20% Hispanics, 11% African-Americans, and 2.5% Asians. The Core performs rigorous standardized medical, neurologic, psychiatric, neuropsychological, neuroimaging, and biological sample evaluation. The Core interacts closely with the Genetics Core in genotyping, storage, and disbursement of samples. The Core works integrally with the Data Core to ensure standardized, high quality, complete data collection including the Uniform Data Set (UDS). Interface with Education Core improves visibility and understanding of diseases, clinical trials, and autopsy program. Coordination with Neuropathology Core results in maximizing utility of brain tissue for genetic, mitochondrial, epigenetic, biochemical, proteomic, and gene expression investigations. Subjects enroll in affiliated federal, foundation, and pharmaceutical company funded research studies. These include clinical drug trial, genetic epidemiology, neuroimaging and neuropsychological studies, and research into risk factors, predictors, and contributing conditions in cognitive change during aging and dementia.

临床核心是 ADRC 的关键资源。主要目标是：(1) 招募、评估、描述和跟踪来自不同种族背景的非痴呆、患有轻度认知障碍或患有阿尔茨海默病或其他形式痴呆的老年人； (2) 为中心和国家阿尔茨海默病协调中心 (NACC) 获取并维护有关这些受试者的高质量数据； (3) 提供良好的特性 临床试验和其他相关研究项目的患者； (4) 进行尸检 旨在最大限度地提高神经病理学核心的实用性和材料数量的计划。目标是增进对不同文化、种族和社会经济背景的个体轻度认知障碍和痴呆病因的了解，改善早期发现；提高痴呆症鉴别诊断的准确性。受试者是从哥伦比亚大学神经学研究所、纽约州精神病学研究所、哈莱姆医院卫星中心运营的记忆中心招募的 来自从附近合作机构伊莎贝拉老年中心接受医疗保健的志愿者和社区居民。临床核心招募的样本包括约 20% 的西班牙裔、11% 的非洲裔美国人和 2.5% 的亚洲人。核心执行严格的标准化医学、神经病学、精神病学、神经心理学、神经影像学和生物样本评估。核心与核心紧密互动 样本基因分型、储存和分配的遗传学核心。核心与数据核心集成工作，以确保标准化、高质量、完整的数据收集，包括统一数据集（UDS）。 与教育核心的接口提高了对疾病、临床试验和尸检计划的可见性和理解。与神经病理学核心的协调可以最大限度地利用脑组织进行遗传、线粒体、表观遗传、生化、蛋白质组和基因表达研究。受试者参加附属的联邦、基金会和制药公司资助的研究。这些包括临床 药物试验、遗传流行病学、神经影像学和神经心理学研究，以及对衰老和痴呆期间认知变化的危险因素、预测因素和影响条件的研究。