NEUROPATHOLOGY CORE

神经病理学核心

• 批准号: 8441027
• 负责人: Jean Paul Vonsattel
• 金额: $ 24.78万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441027
• 关键词: NEUROPATHOLOGY; CORE

PROJECT SUMMARY (See instructions): The chief function of the Neuropathology Core (NC) is to provide state of the art diagnostic services, to set up and maintain a collection of optimally prepared brain samples, and to supply samples for cutting edge research to investigators of the Center, affiliated Centers, and to outside neuroscientists conducting research into neurodegenerative diseases. Because humans are the only known species to naturally develop Alzheimer disease (AD) or related illnesses, the availability of carefully prepared postmortem samples is essenfial despite the existence of valuable transgenic animal models. Thus, human fissue-dependent studies require that the diagnostic categorization of samples of interest is as accurate as possible. This tissue must be made available quickly following the receipt of a request to enhance laboratory efficiency and productivities. Therefore, the specific aims of NC are: 1. To establish an accurate diagnosis on all brains obtained for the Center including clinico-pathological interpretations of the findings, which are recorded within two standardized reports; a) a text-based for clinicians and medical files, and b) a quantification-based report. The quantificafion-based report provides data to the Clinical Care / Data Management, and to the National Alzheimer's Coordinafing Committee (NACC) in compliance with National Institute on Aging (NIA) requirements. Furthermore, it is used for identifying the samples in storage with variables matching those specified by requestors; 2. To obtain brain samples for tissue-dependent fresh frozen studies with or without requirement of cellular morphology preservation, which are ready for immediate disbursement once categorized; and formalin fixed samples; 3. To organize the collecfion of samples, maintain it safely, and select among the samples in storage the ones that best match the requirement of a specific study with subsequent distribution within five working days from the time the receipt of the request; 4. To teach clinicians, trainees, and neuroscientists the neuropathology of the demenfias, and to assist in correlating findings made in transgenic animal models with those usually occurring in the human brains; and 5. To cooperate with other Centers including the Nafional Institute of Neurological Disorders and Stroke (NINDS) supported Udall Center.

项目摘要（参见说明）： 神经病理学核心 (NC) 的主要职能是提供最先进的诊断服务，建立和维护一系列经过最佳准备的脑样本，并向中心、附属中心、以及从事神经退行性疾病研究的外部神经科学家。由于人类是唯一已知会自然罹患阿尔茨海默病 (AD) 或相关疾病的物种，因此精心准备的尸检样本的可用性非常有限 尽管存在有价值的转基因动物模型，但它仍然是必不可少的。因此，人类组织依赖性研究要求感兴趣样本的诊断分类尽可能准确。在收到提高实验室效率和生产力的请求后，必须迅速提供该组织。因此，NC 的具体目标是： 1. 对中心获得的所有大脑进行准确的诊断，包括对结果的临床病理学解释，并将其记录在两份标准化报告中； a) 供临床医生和医疗档案使用的基于文本的报告，以及 b) 基于量化的报告。基于量化的报告根据国家老龄化研究所 (NIA) 的要求向临床护理/数据管理和国家阿尔茨海默病协调委员会 (NACC) 提供数据。此外，它还用于识别存储中的样本，其变量与请求者指定的变量相匹配； 2. 获取用于组织依赖性新鲜冷冻研究的脑样本，无论是否需要保存细胞形态，这些样本一旦分类即可立即支付；和福尔马林固定样品； 3.组织样本采集、安全保存，并在收到请求之日起5个工作日内从储存的样本中选择最符合特定研究要求的样本进行后续分发； 4. 向临床医生、实习生和神经科学家传授痴呆症的神经病理学知识，并协助将转基因动物模型中的发现与人脑中通常发生的发现联系起来； 5. 与其他中心合作，包括国家神经疾病和中风研究所 (NINDS) 支持的 Udall 中心。