STRUCTURE OF POTASSIUM CHANNELS

钾通道的结构

• 批准号: 8361634
• 负责人: RODERICK MACKINNON
• 金额: $ 0.55万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361634
• 关键词: Asthma; Atrial Fibrillation; Blood Vessels; Funding; G-Protein Signaling Pathway; GTP-Binding Proteins; Grant; Heart Rate; Ion Channel; Membrane; Membrane Potentials; Molecular Conformation; National Center for Research Resources; Neurons; Potassium Channel; Principal Investigator; Process; Property; Research; Research Infrastructure; Resources; Rest; Signal Transduction; Source; Structure; United States National Institutes of Health; brain cell; cell type; cost; hypertension treatment; inward rectifier potassium channel; respiratory smooth muscle; response; structural biology; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our research at NECAT aims to decipher the gating mechanisms and pharmacological properties of various eukaryotic K+ ion channels. The first channel is the voltage-dependent K+ channel, which opens in response to changes in membrane voltage and is responsible for producing electrical signals in brain cells. We are aiming to determine structures of intermediate gating states to understand how membrane voltage drives the channel between closed and opened conformations. The second channel is the eukaryotic inward rectifier K+ channel, which controls the resting membrane potential in many neurons. The third channel is the G-protein-gated channel, which opens in response to the stimulation of G-proteins signaling pathways. This channel type regulates heart rate, among other processes, and is an important potential target for the treatment of atrial fibrillation. The fourth channel is the high-condcutance Ca2+and voltage-dependent K+ channel. This channel functions in various cell types, including vascular and airway smooth muscle. It is a potential target for the treatment of hypertension and asthma.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们在NECAT的研究旨在破译各种真核K+离子通道的门控机制和药理特性。第一个通道是电压依赖性的K+通道，该通道响应膜电压的变化而打开，并负责在脑细胞中产生电信号。我们的目标是确定中间门控状态的结构，以了解膜电压如何驱动封闭和打开的构象之间的通道。第二个通道是真核内向整流器K+通道，该通道控制许多神经元中的静膜电位。第三个通道是G蛋白门控通道，该通道响应于G蛋白信号通路的刺激而打开。该通道类型调节心率，除其他过程外，它是治疗房颤的重要潜在目标。第四通道是高示例性Ca2+和电压依赖性K+通道。该通道在各种细胞类型中起作用，包括血管和气道平滑肌。它是治疗高血压和哮喘的潜在目标。