STRUCTURAL STUDIES OF EPH RECEPTORS AND EPHRINS

EPH 受体和 EHRINS 的结构研究

• 批准号: 8361611
• 负责人: DIMITAR B NIKOLOV
• 金额: $ 3.47万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361611
• 关键词: Binding; Biochemical; Eph Family Receptors; Ephrins; Funding; Grant; Henipavirus; Ligands; Methods; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; Structure; United States National Institutes of Health; X-Ray Crystallography; cell attachment protein; cost; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We use X-ray crystallography, combined with other biophysical and biochemical methods, to study the structure and function of the Eph receptors and their interactions with the ephrin ligands. We also study the interactions of Ephs and ephrins with other binding partners, including the Henipavirus cell-attachment proteins.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们利用X射线晶体学，结合其他生物物理和生化方法，研究Eph受体的结构和功能及其与肝配蛋白配体的相互作用。 我们还研究了 Ephs 和肝配蛋白与其他结合伙伴（包括亨尼帕病毒细胞附着蛋白）的相互作用。