FMRI IN IRRITABLE BOWEL SYNDROME

FMRI 在肠易激综合症中的应用

• 批准号: 8363458
• 负责人: Stacey Cromer-Berman
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363458
• 关键词: Abdominal Pain; Air; Brain; Brain scan; Clinical; Constipation; Diarrhea; Disease; Economic Inflation; Esthesia; Funding; Grant; Hour; Irritable Bowel Syndrome; Magnetic Resonance Imaging; Medical; Modeling; National Center for Research Resources; Pain; Positioning Attribute; Principal Investigator; Procedures; Pump; Rectum; Research; Research Infrastructure; Resources; Source; Stimulus; Structure; Syndrome; United States National Institutes of Health; computational anatomy; cost; effective therapy; magnetic field; pressure; rectal; research study; response; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are investigating possible causes of a disease called irritable bowel syndrome (IBS). IBS is a medical condition characterized by abdominal pain, diarrhea and constipation for which there are few effective treatments. We believe that part of the syndrome might be caused by an abnormal response to rectal sensation in the brain. To investigate this possibility we need to take pictures of volunteers ' brains while they receive a mildly painful and discomforting rectal stimulus. The pictures are taken using a magnetic resonance imaging (MRI) machine. The MRI uses a very powerful magnetic field that can detect differences in the structure and function or activity of the brain. Differences between normal subjects and subjects with IBS in the brain response to rectal pressure will help in the guidance of future research and clinical therapy. Each subject will be involved in one experimental session. A balloon that can be inflated with a barostat (air pump) will be inserted into the rectum. Preliminary inflations will be rated for intensity and discomfort to insure that the inflation levels used in the experiment are not overly painful. Subjects will then be positioned in the MRI scanner according to standard procedure. For 45 minutes subjects will rate the intensity of 90 15 second balloon inflations while their brains are scanned. With breaks as needed, each session will last from one to two hours.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们正在调查肠易激综合症 (IBS) 疾病的可能原因。 IBS 是一种以腹痛、腹泻和便秘为特征的疾病，目前几乎没有有效的治疗方法。我们认为，该综合征的一部分可能是由大脑对直肠感觉的异常反应引起的。为了研究这种可能性，我们需要在志愿者接受轻微疼痛和不适的直肠刺激时拍摄他们的大脑照片。这些照片是使用磁共振成像（MRI）机器拍摄的。 MRI 使用非常强大的磁场，可以检测大脑结构和功能或活动的差异。正常受试者和 IBS 受试者在大脑对直肠压力反应方面的差异将有助于指导未来的研究和临床治疗。 每个受试者将参与一次实验。将一个可用恒压器（气泵）充气的气球插入直肠。初步充气将根据强度和不适程度进行评级，以确保实验中使用的充气水平不会太痛苦。然后根据标准程序将受试者放置在 MRI 扫描仪中。 受试者将在 45 分钟内对 90 个 15 秒的气球充气强度进行评分，同时扫描他们的大脑。 根据需要休息，每次会议将持续一到两个小时。