EVALUATION OF INTRAMYOCELLULAR LIPID CONTENT (IMCL) IN SKELETAL MUSCLE BY MRS

通过 MRS 评估骨骼肌中肌细胞内脂质含量 (IMCL)

• 批准号: 8362866
• 负责人: LISA S CHOW
• 金额: $ 0.38万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362866
• 关键词: Evaluation; Fatty acid glycerol esters; Funding; Grant; Insulin Resistance; Lipids; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; NMR Spectroscopy; National Center for Research Resources; Non-Insulin-Dependent Diabetes Mellitus; Principal Investigator; Research; Research Infrastructure; Resources; Skeletal Muscle; Source; United States National Institutes of Health; cost; physical property

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. While intramyocellular fat levels are comparable between subjects with type 2 diabetes in endurance athletes, there is a marked disassociation with insulin resistance. In untrained subjects, particularly subjects with type 2 diabetes, there is a positive correlation of intramyocellular fat with insulin resistance. In endurance athletes, there is an inverse correlation of intramyocellular fat with insulin resistance. We hypothesize that the observed paradox of intramyocellular fat with insulin resistance can be explained by differences in the physical properties of the intramyocellular fat. We propose to measure these differences in physical properties by magnetic resonance spectroscopy

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 虽然耐力运动员的 2 型糖尿病受试者的肌细胞内脂肪水平相当，但与胰岛素抵抗明显无关。 在未经训练的受试者中，尤其是患有 2 型糖尿病的受试者中，肌细胞内脂肪与胰岛素抵抗呈正相关。 在耐力运动员中，肌细胞内脂肪与胰岛素抵抗呈负相关。 我们假设观察到的肌细胞内脂肪与胰岛素抵抗的悖论可以通过肌细胞内脂肪的物理性质的差异来解释。我们建议通过磁共振波谱来测量这些物理性质的差异