TRANSCRIPTION FACTOR A, MITOCHONDRIAL

转录因子 A，线粒体

• 批准号: 8363355
• 负责人: MIGUEL GARCIA-DIAZ
• 金额: $ 0.46万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363355
• 关键词: Affect; Aging; Cell Respiration; Cell physiology; Crystallography; Funding; Genetic; Genetic Transcription; Grant; Laboratories; Lead; Light; Link; Mitochondria; Mitochondrial Diseases; National Center for Research Resources; Nerve Degeneration; Nuclear Hormone Receptors; Organelles; Oxidative Phosphorylation; Physiological Processes; Principal Investigator; Process; Regulation; Research; Research Infrastructure; Resources; Source; Structural Biochemistry; Synchrotrons; Therapeutic; United States National Institutes of Health; cost; human disease; mitochondrial genome; mtTF1 transcription factor; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Mitochondria are the organelles responsible for oxidative phosphorylation. The efficiency and regulation of oxidative metabolism is critical to sustain different physiological processes. Mitochondrial deficiencies that affect oxidative metabolism are linked to aging, neurodegeneration and a variety of genetic mitochondrial diseases. Mitochondrial function is strictly dependent on the expression of the mitochondrial genome, and mitochondrial gene transcription is a key link in this process. Our laboratory is currently trying to understand the structural biology and biochemistry of the mitochondrial transcription machinery and to study its control by nuclear hormone receptors. Elucidating the mechanisms of regulation of this key cellular process has important implications for a number of human diseases and may lead to new potential avenues for therapeutics.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 线粒体是负责氧化磷酸化的细胞器。氧化代谢的效率和调节对于维持不同的生理过程至关重要。影响氧化代谢的线粒体缺陷与衰老，神经变性和多种遗传线粒体疾病有关。线粒体功能严格取决于线粒体基因组的表达，线粒体基因转录是此过程中的关键联系。我们的实验室目前正试图了解线粒体转录机械的结构生物学和生物化学，并通过核激素受体研究其控制。阐明这种关键细胞过程调节的机制对许多人类疾病具有重要意义，并可能导致治疗疗法的新潜在途径。