IMAGING OF FORMALIN-FIXED HUMAN PROSTATES AND REGISTRATION WITH HISTOLOGY

福尔马林固定的人类前列腺成像和组织学登记

• 批准号: 8363204
• 负责人: Kathryn Radabaugh Nightingale
• 金额: $ 0.31万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363204
• 关键词: Address; Data; Ensure; Excision; Formalin; Funding; Grant; Histologic; Histology; Human; Image; Magnetic Resonance Imaging; Metals; Microscopy; Modality; National Center for Research Resources; Principal Investigator; Prostate; Research; Research Infrastructure; Resolution; Resources; Sampling; Signal Transduction; Source; Structure; Three-Dimensional Image; Ultrasonography; United States National Institutes of Health; Work; cost; image registration; in vivo; sample fixation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. 7T MR imaging will provide high-resolution fully 3D images of formalin fixed excised prostates that will be used to co-register information between in-vivo MR and ultrasound imaging data and histology results. We will obtain high-resolution MR images of human prostates ex vivo using your 7T magnet. We plan to use them to to correlate the structures with the histologic sections that are obtained after imaging, and with both MR and ARFI/Ultrasound images obtained in vivo prior to prostate excision. Christina will also be working on the image registration between all the modalities. It will likely be 2-3 samples every other week, and we would want to snap and x-ray them first to ensure there are no staples/metal in them, and then obtain the MR image volume at the highest resolution possible. We will address concerns that the formalin fixation reduces T2, and thus signal, so, discussion needs to take place.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 7T MR成像将提供福尔马林固定切除的前列腺的完全3D图像，这些图像将用于在体内MR和超声影像学数据和组织学结果之间共同注册信息。 我们将使用您的7T磁铁在体内获得人类前列腺的高分辨率MR图像。 我们计划使用它们将结构与成像后获得的组织学部分相关联，以及在前列腺切除之前在体内获得的MR和ARFI/ARFI/超声图像。克里斯蒂娜（Christina）还将致力于所有方式之间的图像注册。它可能每隔一周是2-3个样本，我们希望首先拍摄和X射线检查，以确保其中没有主食/金属，然后以最高分辨率获得MR图像量。 我们将解决福尔马林固定会减少T2的问题，从而发出信号，因此需要进行讨论。