STRUCTURAL GENOMICS FOR DIFFICULT TARGETS AND/OR DISEASE-RELATED PROTEINS

困难目标和/或疾病相关蛋白质的结构基因组学

• 批准号: 8362117
• 负责人: LI-WEI HUNG
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362117
• 关键词: Biological; Communities; Crystallography; Disease; Drug Delivery Systems; Funding; Grant; Mycobacterium tuberculosis; National Center for Research Resources; Principal Investigator; Protein Structure Initiative; Proteins; Radiation; Research; Research Infrastructure; Resources; Source; Structure; Synchrotrons; Technology; United States National Institutes of Health; cost; innovation; protein structure; research study; structural biology; structural genomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Structural genomics has reached an era where focus has been shifted to making more substantial contribution to the biological community. Our group operates the x-ray crystallography facility of two PSI-II centers ? the Integrated Center for Structure and Function Innovation (ISFI) and the TB Structural Genomics Consortium (TBSGC). The two centers focus on develop technologies to solve crystal structures of important but difficult targets (ISFI), and to solve those of important drug targets of Mycobacterium tuberculosis. Because of the difficulty of the targets, most of the crystals are difficult to obtain and often very small. Well managed and intense synchrotron sources optimized for protein crystallography are usually the only hope in conducting effective diffraction experiments. Characterizing and solving the crystal structures of these proteins of biomedical importance will bring substantial impact to the biological community.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 结构基因组学已经进入了一个焦点已转移到为生物界做出更实质性贡献的时代。 我们的团队运营着两个 PSI-II 中心的 X 射线晶体学设施？结构与功能创新综合中心 (ISFI) 和结核病结构基因组学联盟 (TBSGC)。 这两个中心致力于开发解决重要但困难靶点（ISFI）晶体结构的技术，以及解决结核分枝杆菌重要药物靶点的晶体结构的技术。 由于目标难度大，大多数晶体都很难获得，而且往往非常小。 管理良好且针对蛋白质晶体学优化的强同步加速器源通常是进行有效衍射实验的唯一希望。 表征和解决这些具有生物医学重要性的蛋白质的晶体结构将为生物界带来重大影响。