TYROSINASE AND HEMOCYANIN

酪氨酸酶和血蓝蛋白

• 批准号: 8361080
• 负责人: HEINZ DECKER
• 金额: $ 1.23万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361080
• 关键词: Albinism; Electron Microscopy; Funding; Grant; Hair Color; Hemocyanin; Mammals; Mutation; National Center for Research Resources; Organism; Oxygen; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Wound Healing; cost; macromolecule; melanoma; overexpression; skin color

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Phenoloxidases (POs) occur in all organisms and are involved in skin and hair coloring in mammals, and initiating melanization in wound healing. Mutation or overexpression of PO can cause albinism or melanoma, respectively. SDS can convert inactive PO and the oxygen carrier hemocyanin (Hc) into enzymatically active PO.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 在所有生物体中都发生苯酚氧化酶（POS），并参与哺乳动物的皮肤和头发着色，并在伤口愈合中启动黑色素化。 PO的突变或过表达可能会引起白化病或黑色素瘤。 SDS可以将非活性PO和氧载体血氨酸（HC）转化为酶活性PO。