TECHNIQUES FOR T1P-WEIGHTED IMAGING

T1P 加权成像技术

• 批准号: 8361958
• 负责人: Walter R.T. Witschey
• 金额: $ 1.54万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361958
• 关键词: Acute; Breast; Cartilage; Cartilage injury; Cerebral Ischemia; Clinic; Degenerative polyarthritis; Equilibrium; Funding; Grant; Heterogeneity; Human; Image; Intervertebral disc structure; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Metabolic; Methods; National Center for Research Resources; Physiologic pulse; Preparation; Principal Investigator; Property; Radial; Rattus; Relaxation; Research; Research Infrastructure; Resources; Signal Transduction; Source; Techniques; Time; Tissues; Translations; United States National Institutes of Health; Variant; Water; Weight; base; cost; design; improved; intervertebral disk degeneration; novel; optical imaging; response; time use

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Conventional contrast in magnetic resonance (MR) images is derived from the 1H magnetic relaxation properties of tissues. Variations in longitudinal magnetic relaxation (T1) and transverse magnetic relaxation (T2) distinguish the healthy and pathological states. An unconventional contrast mechanism based on the rotating frame spin-lattice relaxation time T1¿ has shown sensitivity to the diseased states of the human breast, early acute cerebral ischemia in rats, cartilage degeneration during osteoarthritis, posttraumatic cartilage injury and narrowing of lumbar intervertebral discs associated with degenerative disc disease. In addition, functional T1¿ imaging shows both an augmented BOLD signal and improved response to indirectly detected metabolic 17O water. The purpose of this subproject is to develop techniques for T1¿-weighted imaging emphasizing both novel methods and translation to the clinic. Novel Methods 1. Correction for B1 field heterogeneity by an off-resonance rotary echo magnetization preparation pulse sequence. 2. Correction for B0 and B1 field heterogeneity by an integrated spin echo and spin lock magnetization preparation pulse sequence. 3. Steady-state spin lock techniques by integrated spin lock and balanced gradient echo pulse sequence design. Methods for Translation to the Clinic 1. T1¿-prepared centrically reordered multiple gradient echo (balanced and spoiled) for rapid 3D T1¿-weighted image acquisition. 2. Integrated partial Fourier and parallel imaging k-space acquisition for image blur reduction and reduced acquisition time. 3. Decreased imaging time using T1¿-prepared k-space weighted image contrast (T1¿-KWIC) for view sharing of radial projections during k-space acquisition.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 磁共振（MR）图像中的常规对比度是从1H磁弛豫得出的 组织的特性。纵向磁弛豫（T1）和横向磁的变化 放松（T2）区分健康和病理状态。非常规的对比 基于旋转框架旋转晶格松弛时间T1的机制显示出对 人乳房的分离状态，早期的急性脑缺血，软骨变性 在骨关节炎，创伤后软骨损伤和腰椎椎间盘的狭窄 与退行性椎间盘疾病有关。此外，功能性T1€成像显示了 增强大胆信号并改善对间接检测到的代谢17o水的反应。这 该子项目的目的是开发用于T1€加权成像的技术，强调了两者 新方法和转换为诊所。 新方法 1。通过非谐波旋转回声磁化准备B1场异质性的校正 脉冲序列。 2。通过集成的自旋回波和自旋锁对B0和B1场异质性进行校正 磁化制备脉冲序列。 3。通过集成的自旋锁和平衡梯度回声脉冲进行的稳态自旋锁技术 序列设计。 翻译到诊所的方法 1。T1€用于快速3D的中心重新排序多个梯度回声（平衡和变质） T1€ - 加权图像获取。 2。集成的部分傅立叶和并行成像K空间获取用于图像模糊还原和 减少收购时间。 3。使用T1€的k空间加权图像对比度（T1¿-KWIC）减少成像时间 查看k空间获取期间径向预测的共享。