HYPERPOLARIZED 3HE MR-LUNG CANCER LESIONS TAGGED BY TARGETED SPIONS

由靶向 SPION 标记的超极化 3HE MR 肺癌病变

• 批准号: 8363160
• 负责人: Rosa Tamara Branca
• 金额: $ 1.23万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363160
• 关键词: Applications Grants; Area; Collaborations; Data; Feasibility Studies; Funding; Goals; Grant; Histological Techniques; Image; Left; Lesion; Louisiana; Lung; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of lung; Microscopy; National Center for Research Resources; Neoplasm Metastasis; Pilot Projects; Principal Investigator; Protons; Research; Research Infrastructure; Resources; Source; Testing; Translating; United States National Institutes of Health; Universities; cost; in vivo; interest; iron oxide; mouse model; nanoparticle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Warren Group has a long-term collaboration with Carola Leuschner of Louisiana State University to develop super paramagnetic iron oxide nanoparticles (SPIONs) to target cancer. A specific interest is to develop SPIONS that target metastatic lung cancer. This has been achieved and demonstrated by histologic techniques. A subsequent goal is to image the presence of such metasteses in vivo. This is a challenging goal because the primary contrast from SPIONS is to reduce T2*, but lung protons already have very short T2* rendering this effect unobservable. However, this problem is mitigated by using 3He MRI since 3He has a T2* > 15 ms, therefore leaving ample dynamic range for observing T2* reduction in areas of targetted metasteses. Our specific aims in this pilot project are to perform a preliminary feasibility study to test whether 3He MRI can be used to detect lung cancer metastases in mouse models supplied by the Warren group. If we are successful in obtaining this preliminary in vivo data, it would be translated into a grant application.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 Warren 集团与路易斯安那州立大学的 Carola Leuschner 长期合作，开发针对癌症的超顺磁性氧化铁纳米粒子 (SPION)。我们特别感兴趣的是开发针对转移性肺癌的 SPIONS。这已通过组织学技术实现并证明。随后的目标是对体内此类转移的存在进行成像。这是一个具有挑战性的目标，因为 SPIONS 的主要对比是降低 T2*，但肺质子的 T2* 已经非常短，导致这种效应无法观察到。然而，使用 3He MRI 可以缓解这个问题，因为 3He 的 T2* > 15 ms，因此为观察目标转移区域的 T2* 减少留下了充足的动态范围。 我们在这个试点项目中的具体目标是进行初步可行性研究，以测试 3He MRI 是否可以用于检测 Warren 小组提供的小鼠模型中的肺癌转移。如果我们成功获得初步的体内数据，它将转化为拨款申请。