HYPERPOLARIZED 3HE MR-LUNG CANCER LESIONS TAGGED BY TARGETED SPIONS

由靶向 SPION 标记的超极化 3HE MR 肺癌病变

• 批准号: 8363160
• 负责人: Rosa Tamara Branca
• 金额: $ 1.23万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363160
• 关键词: Applications Grants; Area; Collaborations; Data; Feasibility Studies; Funding; Goals; Grant; Histological Techniques; Image; Left; Lesion; Louisiana; Lung; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of lung; Microscopy; National Center for Research Resources; Neoplasm Metastasis; Pilot Projects; Principal Investigator; Protons; Research; Research Infrastructure; Resources; Source; Testing; Translating; United States National Institutes of Health; Universities; cost; in vivo; interest; iron oxide; mouse model; nanoparticle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Warren Group has a long-term collaboration with Carola Leuschner of Louisiana State University to develop super paramagnetic iron oxide nanoparticles (SPIONs) to target cancer. A specific interest is to develop SPIONS that target metastatic lung cancer. This has been achieved and demonstrated by histologic techniques. A subsequent goal is to image the presence of such metasteses in vivo. This is a challenging goal because the primary contrast from SPIONS is to reduce T2*, but lung protons already have very short T2* rendering this effect unobservable. However, this problem is mitigated by using 3He MRI since 3He has a T2* > 15 ms, therefore leaving ample dynamic range for observing T2* reduction in areas of targetted metasteses. Our specific aims in this pilot project are to perform a preliminary feasibility study to test whether 3He MRI can be used to detect lung cancer metastases in mouse models supplied by the Warren group. If we are successful in obtaining this preliminary in vivo data, it would be translated into a grant application.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 沃伦集团（Warren Group）与路易斯安那州立大学的卡罗拉·莱斯纳（Carola Leuschner）进行了长期合作，以开发超级顺磁铁氧化铁纳米颗粒（SPIONS）以靶向癌症。特定的兴趣是开发针对转移性肺癌的SPION。这是通过组织学技术实现和证明的。随后的目标是成像体内这种转移的存在。这是一个具有挑战性的目标，因为SPIONS的主要对比是减少T2*，但是肺质子已经无法观察到非常短的T2*。但是，由于3HE具有T2*> 15 ms，因此可以通过使用3HE MRI来减轻此问题，因此留下了足够的动态范围，以观察靶向转移区域的T2*减少。 我们在该试验项目中的具体目的是进行初步的可行性研究，以测试是否可以使用3HE MRI来检测沃伦组提供的小鼠模型中的肺癌转移。如果我们成功地获得了此初步体内数据，则将其转化为赠款应用程序。