EXPERIMENTAL AND NUMERICAL TESTING OF AN ELASTOMER-TYPE PROSTHETIC DISC

弹性体型假体盘的实验和数值测试

• 批准号: 8359654
• 负责人: Morshed Khandaker
• 金额: $ 2.06万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359654
• 关键词: Applications Grants; Biocompatible Materials; Biological; Biomedical Research; Computer software; Development; Devices; Drops; Educational Curriculum; Elastomers; Elements; Engineering; Equipment; Faculty; Failure; Funding; Future; Goals; Grant; Histocompatibility Testing; Human body; Implant; Intervertebral disc structure; Lateral; Licensing; Mechanics; Modeling; National Center for Research Resources; Oklahoma; Physics; Preparation; Principal Investigator; Property; Prosthesis; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Rotation; Source; Testing; Time; United States National Institutes of Health; Universities; Vertebral column; Work; cost; improved; member; novel; sensor; spine bone structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Over the past years, a tremendous effort has been made to develop an intervertebral disc (IVD) prosthesis with suitable biological, mechanical and transport properties. However, it has been frequently reported that current prostheses undergo failure mainly due to the mismatch between the mechanical properties of the conventional device and the spine segment to be replaced. The long time goal of the PI present work is to develop a novel biomaterial for an intervertebral disc (IVD) prosthesis, and to investigate the static and dynamic mechanical properties of the implanted prosthetic vertebra column. This nanobiomaterial for the implanted vertebra constructs will not only regulate the integration of multiple tissue types, but also maintain long-term functionality when they are introduced into the human body. Experimental and numerical testing will be conducted on the implanted vertebra column under flexion, extension, lateral bending, compression, rotation and sudden drop of loading conditions. The new equipment will be used to construct the experimental setup and numerical (finite element) modeling. The following equipments will be purchased using the equipment grant: six axis loadcell, extensometer and dynamic force sensor. Commercial license of ANSYS, a finite element software, will be purchased using the equipment grant. The equipments will benefit research projects spanning the engineering and physics department at the University of Central Oklahoma. Also, these equipments will assist faculty members at UCO in the preparation of grant applications to support biomedical research projects or curriculum redesign and course development intended to improve the preparation of future biomedical researchers.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 在过去的几年里，人们付出了巨大的努力来开发具有合适的生物、机械和运输特性的椎间盘（IVD）假体。 然而，经常有报道称，当前的假体发生故障的主要原因是传统装置的机械性能与待更换的脊柱段之间不匹配。 PI 目前工作的长期目标是开发一种用于椎间盘 (IVD) 假体的新型生物材料，并研究植入假体脊柱的静态和动态机械性能。 这种用于植入椎骨结构的纳米生物材料不仅能够调节多种组织类型的整合，而且在被引入人体后还能保持长期功能。 将对植入的椎骨在屈曲、伸展、侧向弯曲、压缩、旋转和负载突然下降的条件下进行实验和数值测试。 新设备将用于构建实验装置和数值（有限元）建模。 使用设备补助金将购买以下设备：六轴称重传感器、引伸计和动态力传感器。 将使用设备补助金购买有限元软件 ANSYS 的商业许可证。 这些设备将有利于中央俄克拉荷马大学工程和物理系的研究项目。 此外，这些设备还将协助 UCO 的教职人员准备拨款申请，以支持生物医学研究项目或课程重新设计和课程开发，旨在改善未来生物医学研究人员的准备。