EFFECTS OF AGING ON VACCINE EFFICACY IN NONHUMAN PRIMATE MODELS

非人类灵长类动物模型中衰老对疫苗功效的影响

• 批准号: 8357689
• 负责人: ELLEN KRAIG
• 金额: $ 16.47万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357689
• 关键词: Address; Age; Aging; Antigens; Bacteria; Biomedical Research; Callithrix; Communicable Diseases; Competence; Drug Formulations; Elderly; Funding; Grant; Human; Immune; Immune response; Immunity; Individual; Left; Macaca mulatta; Malignant Neoplasms; Modeling; National Center for Research Resources; Papio; Plague; Population; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Rodent; Source; Testing; United States National Institutes of Health; Vaccines; age effect; age related; cost; immune function; juvenile animal; nonhuman primate; novel vaccines; senescence; vaccine efficacy; vaccine evaluation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The ability of humans to mount an effective immune response declines with age, leaving the elderly susceptible to infectious diseases and cancer. Moreover, vaccines tested in younger individuals are often ineffective in older people. Thus, as new vaccines are developed, it will be extremely important to test these formulations for efficacy in the elderly as well as in the young. While young nonhuman primates have been critical in testing vaccine efficacy for the general human population, a model using old nonhuman primates to assess vaccine protection for the elderly has not been established. We have begun to address this issue and in a recent study, found to our surprise that baboons, a nonhuman primate species used extensively in biomedical research, did not show immune senescence with aging. In fact, when old baboons (19-24 years old) were immunized with LcrV, a protective antigen from the plague bacterium, they responded even better than young animals (2¿ years old). Thus, although age-related loss in immune function has been observed in humans, rodents and a few nonhuman primate species, baboons appear to be unusual; they age without losing immune competence. Therefore, we propose to assess the effects of aging on immunity in three nonhuman primate species (baboons, rhesus macaques, and marmosets) to multiple different antigens.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供 该子项目的主要支持。 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源的子项目可能列出的总成本。 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 人类产生有效免疫反应的能力会随着年龄的增长而下降，使老年人容易感染传染病和癌症，而且，在年轻人身上测试的疫苗往往对老年人无效，因此，随着新疫苗的开发，这种情况将极其严重。虽然年轻的非人类灵长类动物对于测试普通人群的疫苗功效至关重要，但使用老年非人类灵长类动物来评估疫苗对老年人的保护作用的模型尚未建立。我们已经开始着手解决这个问题。在最近的一项研究中，我们惊讶地发现狒狒（一种广泛用于生物医学研究的非人类灵长类动物）并没有随着年龄的增长而表现出免疫衰老。事实上，当年老狒狒（19-24岁）接受LcrV（因此，尽管在人类、啮齿动物和一些非人类灵长类动物中观察到与年龄相关的免疫功能丧失，但它们的反应甚至比年轻动物（2岁）还要好。狒狒似乎很不寻常；它们会衰老而不会丧失免疫能力，因此，我们建议评估衰老对三种非人类灵长类动物（狒狒、恒河猴和狨猴）对多种不同抗原的免疫力的影响。