MOSAIC VACCINE-ELICITED IMMUNE RESPONSES IN RHESUS MONKEYS

马赛克疫苗在恒河猴中引起的免疫反应

• 批准号: 8357984
• 负责人: NORMAN L LETVIN
• 金额: $ 6.84万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357984
• 关键词: Antigens; CD8-Positive T-Lymphocytes; Cellular Immunity; Consensus; Development; Funding; Genes; Genetic Heterogeneity; Genetic Variation; Grant; HIV; HIV vaccine; Immune response; Macaca mulatta; National Center for Research Resources; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Solutions; Source; United States National Institutes of Health; Vaccination; Vaccines; Virus; base; cost; design; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Creation of a successful HIV vaccine will require development of an immunogen that will generate cellular immunity with sufficient cross-clade breadth to deal with the extreme genetic diversity of the virus. Recently it has been suggested that vaccines based on centralized HIV gene sequences might provide a solution to the problem posed by the genetic heterogeneity of the circulating strains of HIV. Both consensus and polyvalent mosaic immunogens are based on centralized gene sequences. The present study was designed to explore the breadth of CD4+ and CD8+ T lymphocyte responses generated by vaccination with polyvalent mosaic as compared to vaccination with consensus immunogens.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 创建成功的HIV疫苗将需要开发免疫原，该免疫原将产生具有足够的跨层宽度的细胞免疫，以应对该病毒的极端遗传多样性。最近，有人提出，基于集中式HIV基因序列的疫苗可能为HIV循环菌株的遗传异质性带来的问题提供了解决方案。 共识和多价镶嵌免疫原均基于集中基因序列。本研究旨在探索与共同体免疫原子疫苗接种相比，通过疫苗接种疫苗接种而产生的CD4+和CD8+ T淋巴细胞反应的广度。