MENINGOCOCCAL VACCINES IN INFANT RHESUS MACAQUES

幼年恒河猴的脑膜炎球菌疫苗

• 批准号: 8357327
• 负责人: Michael B. McChesney
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357327
• 关键词: Adjuvant; Age-Months; Antibodies; Antibody Formation; Antigens; California; Childhood; Environment; Funding; Grant; Housing; Immune system; Infant; Infection; Injection of therapeutic agent; Macaca mulatta; Measures; Meningococcal vaccine; National Center for Research Resources; Neisseria; Neurologic; Polysaccharides; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; Vaccination; bactericide; cost; design; immunogenicity; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Pediatric infection with Neisseria meningititidis remains an important cause of serious illness with neurologic sequellae for which conventional vaccination has been ineffective. Both neutralizing and bactericidal antibodies are protective but the infant immune system does not respond adequately to capsular polysaccharide immunogens. This project tests several meningococcal immunogens formulated with different adjuvants designed to improve the bactericidal antibody response in the infant host. Infant rhesus monkeys, screened for absence of meningoccal antibody and housed in a natural environment, the outdoor field cage, will be immunized with meningococcal vaccines at 3 months of age, followed by a booster injection at 4 months. The titers of bactericidal antibody will be measured in this immunogenicity study.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 脑膜炎奈瑟氏菌的小儿感染仍然是造成常规疫苗接种无效的神经系统peellae的严重疾病的重要原因。中和和杀菌性抗体都是保护性的，但婴儿免疫系统对囊囊多糖免疫剂的反应不足。该项目测试了几种脑膜炎球菌免疫原子，该脑膜炎球菌免疫原子是旨在改善婴儿宿主中杀菌抗体反应的不同佐剂。 婴儿的恒河猴猴子因缺乏脑膜炎抗体而受到筛查，并在自然环境中容纳，室外野外笼子将在3个月大时用脑膜炎球菌疫苗免疫，然后在4个月时进行增强注射。 在这项免疫原性研究中将测量杀菌抗体的滴度。