N-METHYL-D-ASPARTATE (NMDA) RECEPTOR IN ALZHEIMER'S DISEASE

阿尔茨海默病中的 N-甲基-D-天冬氨酸 (NMDA) 受体

• 批准号: 7950816
• 负责人: ANAT BIEGON
• 金额: $ 0.55万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950816
• 关键词: Alzheimer' s Disease; Aspartate; Binding; Blood Circulation; Boxing; Brain; Brain scan; Chemicals; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Human; Image; Institution; Learning; Link; Measures; Memory; Movement; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; Neurotransmitters; New York; Positron-Emission Tomography; Protocols documentation; Radioactive; Research; Research Personnel; Resources; Role; Scanning; Source; Tail; United States National Institutes of Health; Universities; aspartate receptor; radiotracer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine whether the. radiotracer tailed (C]CNS5161 can be used to measure levels of N-methyl-D-aspartate (NMDA) receptors in the normal human brain and to see if these measures give us similar results each tithe. Tice ability to measure the level of NMDA receptors in the human brain will be important in understanding their role" in Alzheimer's Disease (AD). NMDA is a neurotransmitter in the brain that is linked with learning and memory, To image these NMDA receptors;we will use Positron Emission Tomography (PET) and a radiotracer balled (1C]CN55161. This radiotracer was developed to bind (stick) to NMDA receptors. PET is a special camera that takes pictures of the movement of a radiotracer in the body. This radiotracer is a radioactive chemical that is injected into the bloodstream in very small amounts and serves to indicate levels of NMDA receptors. You will receive three Positron Emission Tomography (PET) scans with the same radiotracer. Two of the scans will be done to image your brain. If you choose to go on memantirie therapy under a different protocol at New York University ((NYU), you will return for a third brain scan which is described on the next page in the boxed section.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是确定是否。放射性示踪剂尾部 (C]CNS5161 可用于测量正常人脑中 N-甲基-D-天冬氨酸 (NMDA) 受体的水平，并查看这些测量是否每次都能给出相似的结果。测量 NMDA 水平的能力人脑中的受体对于理解它们在阿尔茨海默病 (AD) 中的作用非常重要。NMDA 是大脑中与学习和记忆相关的神经递质，对这些 NMDA 进行成像受体；我们将使用正电子发射断层扫描 (PET) 和放射性示踪剂球 (1C]CN55161。这种放射性示踪剂是为了结合（粘）到 NMDA 受体而开发的。PET 是一种特殊的相机，可以拍摄放射性示踪剂在体内的运动照片这种放射性示踪剂是一种放射性化学物质，以极少量注入血液中，用于指示 NMDA 受体的水平。您将接受三项正电子发射断层扫描。使用相同的放射性示踪剂进行 (PET) 扫描，以对您的大脑进行成像。如果您选择在纽约大学 ((NYU)) 接受不同方案的记忆疗法，您将返回进行第三次脑部扫描。这将在下一页的方框部分中进行描述。