ASTHMA AND BREATHLESSNESS IN SCHOOL AGE CHILDREN

学龄儿童的哮喘和呼吸困难

• 批准号: 7951475
• 负责人: THOMAS A. PLATTS-MILLS
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951475
• 关键词: Advertisements; Age; Allergic; Asthma; Child; Clinic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Diagnostic; Dyspnea; Enrollment; Funding; Grant; Hospitals; Inflammation Mediators; Institution; Non obese; Obesity; Pilot Projects; Research; Research Personnel; Resources; School-Age Population; Source; Students; United States National Institutes of Health; high school; inflammatory marker; tool; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A pilot study enrolling 50 High School students age 12-19 (30 MD diagnosed, obese asthmatics, referred to our clinic for suspected asthma or by advertisement and 20 non-asthmatic controls) will be conducted in a hospital setting to investigate the relationship between breathlessness, obesity, and asthma. Our hypothesis is that a significant portion of obese children complaining of breathlessness will be due to deconditioning rather than asthma. Accordingly the profile of the inflammatory mediators will reflect such a trend by showing increased amounts of Th2, allergic inflammatory mediators in asthmatics while increased amounts of Th1 inflammatory mediators in obese, non-asthmatics. It is possible that these inflammatory marker profiles could be used as a diagnostic tool to help distinguish subjects with asthma from those who are only deconditioned.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 一项试点研究将在医院环境中进行，招募 50 名 12-19 岁的高中生（30 名经 MD 诊断的肥胖哮喘患者，因疑似哮喘或通过广告转诊至我们诊所，以及 20 名非哮喘对照者），以调查呼吸困难与呼吸困难之间的关系、肥胖和哮喘。 我们的假设是，抱怨呼吸困难的肥胖儿童中有很大一部分是由于体质失调而不是哮喘。 因此，炎症介质的概况将反映这样的趋势，即哮喘患者中Th2、过敏性炎症介质的量增加，而肥胖、非哮喘患者中Th1炎症介质的量增加。 这些炎症标记物谱可能可以用作诊断工具，以帮助区分患有哮喘的受试者和那些仅状况不佳的受试者。