PAROXETINE EFFECT ON RESPONSE TO MENTAL STRESS DURING CIGARETTE SMOKING

帕罗西汀对吸烟期间精神压力反应的影响

• 批准号: 7951689
• 负责人: MICHAEL KOTLYAR
• 金额: $ 5.16万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951689
• 关键词: Aftercare; Cardiovascular system; Cigarette; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Measures; Paroxetine; Placebos; Psyche structure; Research; Research Personnel; Resources; Smoke; Smoker; Smoking; Source; Speech; Stress; United States National Institutes of Health; Visit; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is assessing the effect of 1 month of paroxetine treatment on cardiovascular response and subjective discomfort during 2 mental stress tasks in smokers immediately after smoking a cigarette. Each subject receives one month of either paroxetine or placebo after which they return to the GCRC for a visit during which cardiovascular response is measured while performing two tasks expected to result in some mental stress. These tasks consist of giving a short speech and performing a mental arithmetic task. For the following month, subjects receive the alternate treatment after which response to the stress tasks is measured again.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究正在评估帕罗西汀治疗 1 个月对吸烟者在吸烟后立即进行的 2 项精神压力任务中的心血管反应和主观不适的影响。 每个受试者接受一个月的帕罗西汀或安慰剂治疗，之后他们返回 GCRC 进行访问，在访问期间测量心血管反应，同时执行两项预计会导致一些精神压力的任务。这些任务包括发表简短演讲和执行心算任务。 在接下来的一个月中，受试者接受替代治疗，然后再次测量对压力任务的反应。