Medication development of non-addicting opioid analgesics

非成瘾阿片类镇痛药的药物开发

• 批准号: 8336473
• 负责人: Richard Rothman
• 金额: $ 36.85万
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336473
• 关键词: Adopted; Adverse effects; Agonist; Analgesics; Biological Factors; Blood - brain barrier anatomy; Cell Culture Techniques; Chinese Hamster Ovary Cell; Collaborations; Constipation; Dependence; Development; Evaluation; Goals; Hydrocodone/Acetaminophen; Journals; Manuscripts; Morphine; Mus; Narcotic Analgesics; Opioid; Opioid Analgesics; Oxycodone; Pain; Paper; Pathway interactions; Peptides; Pharmaceutical Chemistry; Pharmaceutical Preparations; Preparation; Publications; Publishing; Reporting; Research; Research Institute; Seminal; Surveys; System; Therapeutic Agents; Ventilatory Depression; Vicodin; Work; addiction; base; delta opioid receptor; design; naltrindole; prescription opioid; prevent; salvinorin A; small molecule; trend

Significant progress was made in the last reporting period, resulting in five publications. One of these papers was a review article published in Pharmacological Reviews, a very high impact journal. The publication of this paper reflects the overall impact of our collaborative work with Dr. Prisinzano on the synthesis and evaluation of compounds related to Salvinorin A. Our collaborative efforts with Dr. Rices group yielded three publications in high impact Medicinal Chemistry journals. Our work with Dr. Prisinzano led to ne publication in the Journal of Natural Products, a leading journal for this type of work. Several manuscripts are in preparation and should be published by the next reporting period.

在最后一个报告期间取得了重大进展，导致五个出版物。其中一篇论文是一篇评论文章，发表在《药理学评论》上，这是一本非常高影响的杂志。本文的出版反映了我们与Prisinzano博士合作对与Salvinorin A相关的化合物的合成和评估的总体影响。我们与RICES Groups的合作努力在高影响医学化学期刊上产生了三本出版物。我们与Prisinzano博士的合作导致NE在《天然产品杂志》上发表，这是这类工作的主要日记。几个手稿正在准备，应在下一个报告期之前发表。