Cervical cancer and human papillomavirus (HPV) infection

宫颈癌和人乳头瘤病毒 (HPV) 感染

• 批准号: 8349558
• 负责人: Nicolas Wentzensen
• 金额: $ 124.81万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8349558
• 关键词: American; Anus; Biological Markers; Biopsy; California; Case-Control Studies; Cervical; Cervical Cancer Screening; Clinical Management; Clinical Trials; Country; Cross-Sectional Studies; Detection; Diagnostic; Endocervix; Epidemiology; Event; Exocervix; Freezing; Genotype; HIV; HIV Seropositivity; Human Papillomavirus; Human papilloma virus infection; Human papillomavirus 16; India; Integration Host Factors; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Methods; Methylation; Minor; Molecular; Natural History; Neoplasms; Oklahoma; Prevention Research; Prevention strategy; Progressive Disease; Research; Resources; Risk; Screening Result; Screening procedure; Sexually Transmitted Agents; Specimen; Staging; Testing; Viral; Woman; cancer risk; cervical cancer prevention; follow-up; improved; men who have sex with men; novel

SUCCEED directed by Dr. Wentzensen is a cross-sectional study among women referred for abnormal cevrical cancer screening results focused on the identification of biomarkers of risk at each progressive disease stage, aimed to identify the molecular events that are necessary and sufficient for progression to cervical cancer. Frozen specimens, often multiple, from 2,500 women with varying grades of cervical neoplasia (including the ectocervix, transformation zone, and endocervix) have already been collected. In a new study, the Biopsy Study conducted at the same center in Oklahoma, Dr. Wentzensen is investigating the earliest discernible transitions from HPV infection to CIN3 and the best methods for colposcopic detection of CIN3 to improve current cervical cancer prevention strategies. The ALTS clinical trial evaluated management options for women with abnormal cervical cancer screening results and has been completed several years ago. The specimens collected in women with minor cytological abnormalities and 2 year follow up still serve as an important resource to evaluate HPV tests and novel biomarkers, such as viral methylation. The Anal Cancer Screening Study in HIV positive men who have sex with men is conducted with Kaiser Permanente Northern California to identify the HPV genotype attribution in anal precancer and to study biomarkers for anal cancer screening The Intramural to India project is a new effort to study cervical cancer precursors among HIV-infected women in India. The case control study of invasive cervical cancer in four Latin-American countries is an important resource to study sero-epidemiologic markers of cervical cancer risk.

SUCCEED 由 Wentzensen 博士指导，是一项针对宫颈癌筛查结果异常的女性的横断面研究，重点是识别每个进展性疾病阶段的风险生物标志物，旨在识别进展为宫颈癌所必需和充分的分子事件。癌症。已经收集了来自 2,500 名患有不同级别宫颈肿瘤（包括子宫颈外层、转化区和子宫颈内膜）的女性的冷冻标本（通常是多个）。在俄克拉荷马州同一中心进行的一项新研究中，Wentzensen 博士正在研究从 HPV 感染到 CIN3 的最早可辨别的转变，以及阴道镜检测 CIN3 的最佳方法，以改进当前的宫颈癌预防策略。 ALTS 临床试验评估了宫颈癌筛查结果异常女性的治疗方案，并于几年前完成。在有轻微细胞学异常的女性中收集的样本和 2 年随访仍然是评估 HPV 检测和新型生物标志物（例如病毒甲基化）的重要资源。与北加州凯撒医疗机构 (Kaiser Permanente) 合作，对男男性行为者的艾滋病毒阳性男性进行肛门癌筛查研究，以确定肛门癌前病变的 HPV 基因型归因，并研究肛门癌筛查的生物标志物 印度校内项目是研究宫颈癌的一项新努力印度艾滋病毒感染妇女中的癌症前兆。四个拉丁美洲国家的浸润性宫颈癌病例对照研究是研究宫颈癌风险血清流行病学标志物的重要资源。