East Carolina University Bariatric Surgery Clinical Center

东卡罗莱纳大学减肥外科临床中心

• 批准号: 7893168
• 负责人: WALTER Julius PORIES
• 金额: $ 46.2万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7893168
• 关键词: Achievement; Address; African American; Age; Characteristics; Clinical; Community Hospitals; Data; Enrollment; Genetic Markers; Hispanics; Individual; Link; Metabolism; Metric; Obesity; Operative Surgical Procedures; Outcome; Participant; Patients; Population; Process; Recruitment Activity; Research Infrastructure; Serological; Site; Subgroup; Surgeon; System; Universities; Vital Status; bariatric surgery; care delivery; clinical care; clinical research site; cohort; economic outcome; follow-up; health economics; male; operation; patient population; psychosocial

DESCRIPTION (provided by applicant): LABS was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese. LABS aims to explore relationships of patient characteristics, clinical conditions, serologic and genetic markers, process of care, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS in its first 5 years have been to define the domains of exploration, identify appropriate metrics and enroll 5105 participants in LABS land achieve vital status data for 99% due for at 30 days post-surgery. In addition, 1947 participants in LABS 2 have been recruited with data collected for 91% for 6 months follow-up. An extension of LABS would build on the rigorous research infrastructure across 10 clinical sites at the 6 clinical centers representing several care delivery systems and patient populations. LABS enrolls patients from 6 academic and 4 community hospitals undergoing operations by 33 surgeons. These sites have created a cohort with considerable diversity of important patient characteristics. LABS includes 21% males (range across sites 16% to 32%), 9% Black/African-Americans (range 0% to 24%), 7% Hispanics (range 1% to 16%), 10% age 60+ years (range 5%-18%), and 10% BMI 60+ kg/m2 (range 6% to 27%). These features have been linked to short and long-term outcomes and represent critical subgroups that have not been adequately characterized because they appear infrequently in most single-center cohorts. Importantly, the diversity across sites is more likely to represent the bariatric surgery population in the U.S. than would be possible from any individual site.

描述（由申请人提供）： LABS 旨在解决肥胖和病态肥胖者的减肥手术和新陈代谢中的重要问题。 LABS 旨在探索患者特征、临床状况、血清学和遗传标记、护理过程以及临床、心理社会和健康经济结果之间的关系。 LABS 在前 5 年的主要成就是定义了勘探领域、确定了适当的指标并招募了 5105 名 LABS 参与者，其中 99% 的患者在术后 30 天获得了生命状态数据。此外，LABS 2 已招募 1947 名参与者，其中 91% 的参与者在 6 个月的随访中收集了数据。 LABS 的扩展将建立在代表多个护理服务系统和患者群体的 6 个临床中心的 10 个临床站点的严格研究基础设施的基础上。 LABS 招募来自 6 家学术医院和 4 家社区医院的患者，由 33 名外科医生进行手术。这些网站创建了一个具有相当多样化的重要患者特征的队列。 LABS 包括 21% 男性（范围为 16% 至 32%）、9% 黑人/非裔美国人（范围为 0% 至 24%）、7% 西班牙裔（范围为 1% 至 16%）、10% 年龄在 60 岁以上（范围 5%-18%），以及 10% BMI 60+ kg/m2（范围 6% 至 27%）。这些特征与短期和长期结果相关，并且代表了尚未充分表征的关键亚组，因为它们在大多数单中心队列中很少出现。重要的是，与任何单个站点相比，各个站点的多样性更有可能代表美国减肥手术人群。