Endocrine and Neurobiologic Events Accompanying Puberty

青春期伴随的内分泌和神经生物学事件

基本信息

批准号：
8556991
负责人：
Peter Schmidt
金额：
$ 12.35万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8556991
关键词：
17 year old Adolescence Adrenal Glands Adult Affective Age Animals Appearance Behavior Behavior assessment Brain Brain imaging Brain region Child Cognitive Complex Development Disease Endocrine Endocrinology Environmental Risk Factor Epidemiologic Studies Event Functional Magnetic Resonance Imaging Future Genetic Genetic Variation Growth Hormonal Hormones Human Image Imaging Techniques Institutes Life Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Mental Depression Metabolic Neurobiology Neurons Neurosciences Research Nutritional Oligogenic Traits Outcome Measure Participant Performance Physiological Precocious Puberty Prevalence Prevention Process Puberty Regulation Relative (related person)Relative Risks Research Rewards Risk Schizophrenia Selection Criteria Series Sex Characteristics Staging Steroids Stress Structure Substance abuse problem System Techniques Time Unipolar Depression Woman Work bone age boys developmental neurobiology environmental stressor girls hypothalamic-pituitary-adrenal axis interdisciplinary approach men neuroimaging neuronal patterning neuropsychiatry relating to nervous system reproductive response sexual dimorphism skeletal stressor

项目摘要

Recruitment for this demanding longitudinal study is in its early stages due in part to the successful development of imaging techniques required to measure gonadal volume in these children with Magnetic Resonance Imaging (MRI), the need for a designated functional MRI to be in place for the performance of brain imaging in this longitudinal, repeated measures study, and the successful piloting of several brain-activation paradigms to measure specific neural systems (e.g., the reward system) across puberty in children. Nonetheless, in the past few months, we have screened several children who were excluded from this study because they did not display a normal tempo of growth as determined by skeletal age within one year of chronologic age. Thus, these participants showed evidence of early gonadal activity, and possibly, a subclinical form of precocious puberty that was not consistent with their chronologic age or their Tanner Stage. We wish to investigate the effects of these early changes in gonadal activity on brain structure and function. Most studies of puberty do not include bone age in their selection criteria and findings of alterations in brain function accompanying elevated bone age relative to chronologic age will be an important methodologic consideration to guide future studies of puberty.

这项要求较高的纵向研究的招募工作尚处于早期阶段，部分原因是通过磁共振成像 (MRI) 测量这些儿童性腺体积所需的成像技术的成功开发，需要指定的功能性 MRI 来进行在这项纵向、重复测量研究中脑成像的表现，以及成功试验了几种大脑激活范例来测量儿童整个青春期的特定神经系统（例如奖励系统）。尽管如此，在过去的几个月里，我们筛选了几名被排除在本研究之外的儿童，因为他们在一年内没有表现出由骨龄确定的正常生长速度。因此，这些参与者表现出早期性腺活动的证据，并且可能是一种亚临床形式的性早熟，与他们的实际年龄或坦纳阶段不一致。我们希望研究性腺活动的这些早期变化对大脑结构和功能的影响。大多数青春期研究的选择标准并不包括骨龄，随着骨龄相对于实际年龄升高而导致的脑功能改变的发现将是指导未来青春期研究的重要方法学考虑因素。