Radiation and Free Radical Research Core

辐射和自由基研究核心

• 批准号: 7900763
• 负责人: Douglas Robert Spitz
• 金额: $ 9.09万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900763
• 关键词: Antioxidants; Arts; Autoradiography; Biological Assay; Cancer Biology; Cancer Center Support Grant; Cells; Cesium; Clinical Research; Dose; Dose-Rate; Electron Spin Resonance Spectroscopy; Enzymes; Equipment; Event; Free Radical Formation; Free Radicals; Gamma Rays; Growth; Individual; Ionizing radiation; Knowledge; Measures; Molecular Weight; Neoplasm Metastasis; Nitric Oxide; Oxidants; Prevention; Proteins; Radiation; Radiobiology; Radiometry; Reactive Oxygen Species; Reagent; Research; Research Personnel; Resources; Roentgen Rays; Role; Services; Singlet Oxygen; Source; Sulfhydryl Compounds; Technology; base; cancer therapy; free radical oxygen; oxidative damage; pre-clinical; programs; tool

Radiation and Free Radical Research Core There is growing evidence that oxidative events and free radicals are important in the initiation, growth, invasion, metastasis, prevention and treatment of cancer. The Radiation and Free Radical Research Core (RFRRC) was established to provide free radical and radiation biology expertise, reagents, technologies, and analysis for HCCC investigators doing basic, pre-clinical, and clinical research. The three basic services provided by the core are: 1) Ionizing radiation services (IRS) and phosphorimaging 2) Electron paramagnetic resonance (EPR) to measure oxygen free radicals, singlet oxygen, nitric oxide and the array of related oxidants 3) Antioxidant enzyme services (AES) to modify and measure molecules responsible for free radical formation and oxidative damage in cells such as anti-oxidant proteins and small molecular weight cellular thiols The RFRRC is unique in its ability to provide such knowledge, reagents and resources. While the expertise for the RFRRC is based in the Free Radicals and Cancer Biology Program, the RFRRC has users from all HCCC programs.

辐射和自由基研究核心 越来越多的证据表明氧化事件和自由基在 癌症的发生、生长、侵袭、转移、预防和治疗。辐射 自由基研究核心（RFRRC）的成立旨在提供自由基和 为 HCCC 研究人员提供放射生物学专业知识、试剂、技术和分析 进行基础、临床前和临床研究。核心提供的三大基础服务 是： 1) 电离辐射服务 (IRS) 和磷光成像 2) 电子顺磁共振（EPR）测量氧自由基，单线态 氧气、一氧化氮和一系列相关氧化剂 3) 抗氧化酶服务 (AES)，用于修改和测量负责的分子 细胞中自由基的形成和氧化损伤，例如抗氧化蛋白和 小分子量细胞硫醇 RRRRC 的独特之处在于其提供此类知识、试剂和资源的能力。 虽然 RFRRC 的专业知识基于自由基和癌症生物学 计划中，RFRRC 拥有来自所有 HCCC 计划的用户。