George M O'Brien Kidney Center at Yale

耶鲁大学乔治·M·奥布莱恩肾脏中心

基本信息

批准号：
8539874
负责人：
PETER S. ARONSON
金额：
$ 4.02万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8539874
关键词：
Acute Renal Failure with Renal Papillary Necrosis Animal Model Animals Antibodies Applied Genetics Area Award Basic Science Biological Assay Biology Blood Vessels Canada Cell Line Cell Polarity Cell physiology Cells Cellular Structures Cellular biology Clinical Clinical Investigator Clinical Research Collaborations Communities Complex Country Development Developmental Biology Disease Disease model Electrolytes Epidemiologic Studies Epithelial Epithelial Cells Equilibrium Faculty Financial Support Fostering Functional disorder Funding Funding Agency Gene Mutation Genes Genetic Genetic Medicine Genomics Genotype Goals Grant Health Sciences Human Human Genetics Hypertension In Vitro Individual Inherited Injury Institution Instruction Internal Medicine Investigation KCNJ1 gene Kidney Kidney Diseases Knowledge Leadership Measurement Medical Students Medical center Medicine Mentors Metabolic Methods Michigan Molecular Morphogenesis Mouse Cell Line Mus Mutation Nephrology Nephrons Oregon Organism Patients Pediatrics Phenotype Physicians Physiological Physiology Positioning Attribute Postdoctoral Fellow Prevention Prize Program Research Project Grants Regulatory Pathway Renal function Renal tubule structure Research Research Institute Research Personnel Research Training Resources Scientist Services Syndrome TNFRSF5 gene Technical Expertise Techniques Technology Texas Training Training Programs Transgenic Mice Transgenic Organisms Translational Research Transport Process Universities Virginia Whole Organism authority base career cohort driving force epithelial Na+ channel familial hypertension graduate student human disease in vivo indexing interest kidney cell medical schools member mouse model new technology novel professor programs renal tubular transport translational study wasting

项目摘要

DESCRIPTION, OVERALL (provided by applicant): The overarching goal of the George M. O'Brien Kidney Center at Yale is to facilitate translational and clinical research that will advance the prevention and treatment of kidney diseases. Major themes of the Center are the development and phenotyping of mouse models of renal dysfunction, the identification of simple and complex genetic causes of kidney disease in humans, and the bidirectional exchange of information between mouse and human disease models in order to advance knowledge of human kidney diseases. A critically important benefit of the Yale Center will be to provide renal investigators both at Yale and across the country with access to highly specialized services not otherwise routinely available to support their research. To this end, three Center Cores will be established whose specific objectives are to provide small animal physiology services to allow detailed characterization of renal function at the level of the tubule, the kidney, and the intact organism in normal animals and in animal models of renal injury and kidney disease; provide mouse genetics and cell line services to develop new animal models and kidney cell lines to elucidate the molecular mechanisms underlying the pathophysiology of kidney diseases; and provide human genetics and clinical research services to apply genetic and genomic technologies to the study of human kidney diseases. We have identified a research user base of 51 investigators, including 18 at outside institutions, who have expressed specific interest in using core services of the Yale Kidney Center. A Pilot and Feasibility Program will be established to provide initial project funding for young investigators, to attract new investigators into the field of kidney disease research, and to foster translational and clinical studies directly related to kidney diseases. In addition, an Enrichment Program will be established to promote interdisciplinary interactions and collaborations among renal investigators participating in the Center; facilitate the application of new technologies to kidney disease research; and provide an online index of resources developed in the Center (e.g. antibodies, transgenic mouse lines, cell lines) so that they can be made available to renal investigators both at Yale and other institutions. The Center will also include a Research Training Program to enhance the training of graduate students, medical students, and postdoctoral fellows in kidney disease research in general, and in the specialized methods provided by the Center Cores in particular.

描述，总体（由申请人提供）：耶鲁大学乔治·M·奥布莱恩肾脏中心的总体目标是促进转化和临床研究，这将推动预防和治疗肾脏疾病。该中心的主要主题是肾功能障碍小鼠模型的发展和表型，人类肾脏疾病的简单且复杂的遗传原因的鉴定以及小鼠和人类疾病模型之间信息的双向交流，以促进人类的知识肾脏疾病。耶鲁大学中心的至关重要的好处将是在耶鲁大学和全国范围内为肾脏调查人员提供访问高度专业化的服务，而其他常规可用于支持他们的研究。为此，将建立三个中心核心，其具体目标是提供小型动物生理学服务，以允许在小管，肾脏和正常动物中的肾功能和完整的有机体和肾脏模型中的肾功能详细表征受伤和肾脏疾病；提供小鼠遗传学和细胞系服务，以开发新的动物模型和肾细胞系，以阐明肾脏疾病病理生理学的分子机制；并提供人类遗传学和临床研究服务，以将遗传和基因组技术应用于人类肾脏疾病的研究。我们已经确定了51名调查人员的研究用户群，其中包括18名外部机构，他们对使用耶鲁肾脏中心的核心服务表达了特别的兴趣。将制定一项试点和可行性计划，为年轻研究人员提供初步的项目资金，吸引新的研究人员进入肾脏疾病研究领域，并培养与肾脏疾病直接相关的翻译和临床研究。此外，还将建立一个丰富计划，以促进参加该中心的肾脏研究人员之间的跨学科互动和合作；促进新技术在肾脏疾病研究中的应用；并提供中心开发的资源索引（例如抗体，转基因小鼠系，细胞系），以便可以向耶鲁大学和其他机构的肾脏研究人员提供它们。该中心还将包括一项研究培训计划，以加强一般肾脏疾病研究中的研究生，医学生和博士后研究员的培训，尤其是中心核心提供的专业方法。