Chile Fetal Alcohol Study

智利胎儿酒精研究

• 批准号: 8351195
• 负责人: James Mills
• 金额: $ 32.4万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8351195
• 关键词: Alcohol abuse; Alcohol consumption; Alcohols; Child; Chile; Data; Exposure to; Eye Abnormalities; Fetal Alcohol Exposure; Fetal Alcohol Syndrome; Fetus; Goals; Growth; Heavy Drinking; Home visitation; Hormones; House Call; Investigation; Life; Mothers; National Institute of Child Health and Human Development; Neural Conduction; Outcome; Oxidative Stress; Pattern; Population; Pregnancy; Premature Birth; Prospective Studies; Reporting; Research Design; Risk; Screening procedure; Universities; Woman; alcohol consumption during pregnancy; alcohol effect; base; drinking; experience; fetal; in utero; offspring; pregnant; prenatal; stillbirth; tool

Our study design enabled us to identify and follow 96 women consuming at least 4 drinks/day during pregnancy. In these women with heavy prenatal alcohol use, there were three stillbirths and one preterm delivery; 98 matched nondrinking women had no stillbirths and two preterm births. Preterm rates did not differ significantly. The stillbirth rate was higher in the exposed group (p = 0.06). Additional investigation showed the stillbirth rate in the exposed population (3.1%) was significantly higher (p = 0.019) than the reported Chilean population rate (0.45%). Our data suggest that heavy alcohol consumption may increase the risk for stillbirth but not preterm delivery. Analysis is now complete and a report has been prepared describing the outcomes of the exposed children based on the amount and pattern of maternal alcohol consumption during pregnancy. The data will be reported soon.

我们的研究设计使我们能够识别并关注96名怀孕期间至少每天喝4杯酒的妇女。在这些患有大量产前饮酒的妇女中，有三分之三和一个早产。 98个匹配的非抓斗妇女没有死胎和两个早产。早产率没有显着差异。暴露组的死产率更高（p = 0.06）。进一步的研究表明，暴露人口的死产率（3.1％）明显高于报道的智利人口率（0.45％）。我们的数据表明，大量饮酒可能会增加死产但不早产的风险。 现在已经完成分析，并准备了一份报告，该报告根据怀孕期间的孕产妇消耗量的数量和模式来描述暴露儿童的结果。 数据将很快报告。