Chile Fetal Alcohol Study

智利胎儿酒精研究

• 批准号: 8351195
• 负责人: James Mills
• 金额: $ 32.4万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8351195
• 关键词: Alcohol abuse; Alcohol consumption; Alcohols; Child; Chile; Data; Exposure to; Eye Abnormalities; Fetal Alcohol Exposure; Fetal Alcohol Syndrome; Fetus; Goals; Growth; Heavy Drinking; Home visitation; Hormones; House Call; Investigation; Life; Mothers; National Institute of Child Health and Human Development; Neural Conduction; Outcome; Oxidative Stress; Pattern; Population; Pregnancy; Premature Birth; Prospective Studies; Reporting; Research Design; Risk; Screening procedure; Universities; Woman; alcohol consumption during pregnancy; alcohol effect; base; drinking; experience; fetal; in utero; offspring; pregnant; prenatal; stillbirth; tool

Our study design enabled us to identify and follow 96 women consuming at least 4 drinks/day during pregnancy. In these women with heavy prenatal alcohol use, there were three stillbirths and one preterm delivery; 98 matched nondrinking women had no stillbirths and two preterm births. Preterm rates did not differ significantly. The stillbirth rate was higher in the exposed group (p = 0.06). Additional investigation showed the stillbirth rate in the exposed population (3.1%) was significantly higher (p = 0.019) than the reported Chilean population rate (0.45%). Our data suggest that heavy alcohol consumption may increase the risk for stillbirth but not preterm delivery. Analysis is now complete and a report has been prepared describing the outcomes of the exposed children based on the amount and pattern of maternal alcohol consumption during pregnancy. The data will be reported soon.

我们的研究设计使我们能够识别并跟踪 96 名在怀孕期间每天至少饮用 4 杯饮料的女性。在这些产前大量饮酒的妇女中，有 3 名死产和 1 名早产； 98 名匹配的不饮酒女性没有死产和 2 例早产。早产率没有显着差异。暴露组的死产率较高（p = 0.06）。进一步调查显示，暴露人群的死产率 (3.1%) 显着高于报告的智利人口死产率 (0.45%) (p = 0.019)。我们的数据表明，大量饮酒可能会增加死产的风险，但不会增加早产的风险。 分析现已完成，并已根据孕期母亲饮酒量和模式编写了一份报告，描述了暴露儿童的结果。 数据将很快报告。