Supplemental Nicotine Administration for Smoking Cessation in PTSD

补充尼古丁治疗创伤后应激障碍 (PTSD) 患者戒烟

基本信息

批准号：
7835787
负责人：
PATRICK S. CALHOUN
金额：
$ 14.13万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-08 至 2012-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7835787
关键词：
Abstinence Address Adult Affect Affective Anxiety Area Behavior Therapy Behavioral Breathing Chronic Cigarette Clinical Cognitive Therapy Data Dependence Development Distress Electronics Emotional Epidemiologic Studies Event Failure General Population Individual Individual Differences Laboratories Lead Maintenance Measures Medical Mental disorders Monitor Moods Nicotine Odds Ratio Participant Patients Persons Phase Physiological Placebos Population Populations at Risk Post-Traumatic Stress Disorders Randomized Relapse Reporting Research Personnel Risk Risk Factors Rosa Self Efficacy Severities Smoke Smoker Smoking Smoking Behavior Social Problems Societies Symptoms Trauma United States Withdrawal Withdrawal Symptom base cigarette smoking craving design diaries distress tolerance effective intervention help-seeking behavior human PTCH2 protein improved innovation nicotine patch nicotine replacement public health relevance smoking cessation smoking relapse treatment response

项目摘要

DESCRIPTION (provided by applicant): Cigarette smoking is highly prevalent among persons with posttraumatic stress disorder (PTSD) and individuals with PTSD have decreased odds of successfully quitting smoking. There is a need to develop more effective interventions and to evaluate factors associated with smoking abstinence in persons with PTSD. The use of supplemental nicotine administration during a "pre-treatment" phase before a targeted quit date is a recent innovative development in smoking cessation therapy and may be particularly helpful in treating smokers with PTSD. The use of supplemental nicotine administration during ad lib smoking for smokers with PTSD is predicted to reduce both the physiological and emotional dependence on inhaled nicotine, thereby increasing the odds of successful smoking cessation. Smokers with PTSD will be randomly assigned to 1 of 2 pre- cessation patch therapy conditions (active patch versus placebo patch) for 2 weeks before a target quit- smoking date. All participants will receive brief cognitive-behavioral therapy (CBT) and will begin standard nicotine replacement therapy (NRT) on their quit day. PTSD symptoms, mood, smoking craving and withdrawal symptoms will be carefully evaluated using electronic diary assessment. The study is designed to address the following aims: (1) To examine the effects of supplemental nicotine administration on PTSD symptoms, mood, craving, and withdrawal through electronic diary assessment, (2) To evaluate the effect of supplemental nicotine administration on quit rates among smokers with PTSD, and (3) To investigate potential predictors of relapse including individual differences in affective style including PTSD symptom severity, baseline mood, anxiety sensitivity, measures of distress tolerance, and self-efficacy. PUBLIC HEALTH RELEVANCE: This study may serve to inform development of easily portable smoking cessation strategies for smokers with PTSD by investigating: 1) the effects of supplemental nicotine administration on craving, mood, PTSD symptoms, and withdrawal; 2) the possible benefit of pre-treatment with nicotine patches on abstinence rates; and 3) risk- factors for smoking relapse in this at risk population.

描述（由申请人提供）：吸烟在创伤后应激障碍 (PTSD) 患者中非常普遍，并且患有 PTSD 的患者成功戒烟的几率较低。有必要制定更有效的干预措施并评估与创伤后应激障碍患者戒烟相关的因素。在目标戒烟日期之前的“预治疗”阶段使用补充尼古丁是戒烟疗法的一项创新发展，可能对治疗患有创伤后应激障碍的吸烟者特别有帮助。患有创伤后应激障碍 (PTSD) 的吸烟者在随意吸烟期间补充尼古丁预计会减少对吸入尼古丁的生理和情感依赖，从而增加成功戒烟的几率。患有 PTSD 的吸烟者将在目标戒烟日期前 2 周被随机分配到 2 种戒除贴片治疗条件中的一种（活性贴片与安慰剂贴片）。所有参与者都将接受简短的认知行为治疗（CBT），并在戒烟日开始标准尼古丁替代疗法（NRT）。将使用电子日记评估仔细评估创伤后应激障碍症状、情绪、吸烟渴望和戒断症状。该研究旨在实现以下目标：(1) 通过电子日记评估检查补充尼古丁对 PTSD 症状、情绪、渴望和戒断的影响，(2) 评估补充尼古丁对戒烟率的影响(3) 调查复发的潜在预测因素，包括情感风格的个体差异，包括 PTSD 症状严重程度、基线情绪、焦虑敏感性、痛苦耐受力测量和自我效能。公共健康相关性：本研究可能有助于为患有创伤后应激障碍 (PTSD) 的吸烟者制定易于携带的戒烟策略，通过调查：1) 补充尼古丁给药对渴望、情绪、创伤后应激障碍 (PTSD) 症状和戒断的影响； 2) 使用尼古丁贴片进行预处理对戒烟率可能有好处； 3) 该高危人群中吸烟复发的危险因素。