2012 Angiotensin Gordon Research Conference and Gordon Research Seminar

2012年血管紧张素戈登研究会议暨戈登研究研讨会

基本信息

批准号：
8319065
负责人：
Kathryn L Sandberg
金额：
$ 1万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8319065
关键词：
AGTR2 gene Achievement Adipose tissue Adult Respiratory Distress Syndrome Amino Acids Aminopeptidase Angiopoietin-2 Angiotensin II Angiotensin Receptor Angiotensinogen Angiotensins Atherosclerosis Award Basic Science Biochemistry Bioluminescence Boxing Cell physiology Chymase Clinical Clinical Research Cloning Collaborations Data Development Diabetes Mellitus Discipline Embryo Energy Transfer Environment Enzymes Epigenetic Process Fostering Functional disorder Future Goals Hormones Human Hypertension Immunity Inactive Renin Inflammation Insulin Kidney Diseases Lead Leadership Malignant Neoplasms Membrane Mental Depression Metabolic MicroRNAs Molecular Molecular and Cellular Biology Multiple Sclerosis Nanotechnology Neurosciences Participant Pathology Pathway interactions Peptide Receptor Peptides Peptidyl-Dipeptidase A Physiological Physiology Proto-Oncogenes Published Comment Regulation Renin Renin-Angiotensin System Research Research Personnel Role Scientist Severe Acute Respiratory Syndrome Signal Transduction Skeletal Muscle Solid Stem cells Students Techniques Tissues Translational Research Travel Virus Receptors aminopeptidase B angiogenesis cancer risk career glutamyl aminopeptidase human disease insight meetings member molecular imaging new therapeutic target novel peer posters prorenin receptor receptor social stem cell biology structural biology symposium vasoconstriction

项目摘要

DESCRIPTION (provided by applicant): The 2012 Angiotensin Gordon Research Conference (GRC) and contiguous Gordon Research Seminar (GRS) will focus on key unpublished developments in the renin angiotensin system (RAS) covering angiogenesis, cancer risk, RAS structural biology, novel signaling mechanisms, stem cell function and diverse aortic pathologies. Topics will include microRNA, the intracrine RAS and epigenetics and also regulation of the RAS in less studied target tissues such as adipose and skeletal muscle. New insights from novel imaging and molecular techniques including bioluminescence resonance energy transfer and nanotechnology will be presented. In addition, the latest findings on the least understood members of the RAS cascade including the protein receptor, aminopeptidase A, and chymase will be discussed as well as novel therapeutic targets of the RAS including cancer, depression and multiple sclerosis. The GRS will dovetail to the GRC and will primarily focus on the RAS in development, immunity and inflammation. The primary goals of the GRC and GRS are to: 1) critically examine cutting-edge unpublished data that intertwines basic science with clinical and translational research on the RAS; 2) engage all participants in unfettered frank and analytical discussion of research findings and creative speculation over future implications during the scientific sessions as well as at meals, breaks, and leisure and social activities; 3) foster new collaborative and cross-disciplinary research initiatives spanning the disciplines of biochemistry, molecular and cellular biology, neuroscience, physiology and human pathophysiology; 4) advance the independent scientific careers of students, trainees and early career investigators by providing visibility opportunities through poster sessions, short talks and travel award competitions at the GRC and through the GRS, which is organized by and specifically features students, trainees and young investigators.

描述（由申请人提供）：2012 年血管紧张素戈登研究会议 (GRC) 和相邻的戈登研究研讨会 (GRS) 将重点关注肾素血管紧张素系统 (RAS) 方面未发表的关键进展，涵盖血管生成、癌症风险、RAS 结构生物学、新型信号传导机制、干细胞功能和多种主动脉病理。主题将包括 microRNA、内分泌 RAS 和表观遗传学，以及 RAS 在研究较少的靶组织（如脂肪和骨骼肌）中的调节。将提出来自新颖成像和分子技术（包括生物发光共振能量转移和纳米技术）的新见解。此外，还将讨论 RAS 级联中最不为人所知的成员（包括蛋白质受体、氨肽酶 A 和食糜酶）的最新发现，以及 RAS 的新治疗靶点，包括癌症、抑郁症和多发性硬化症。 GRS 将与 GRC 相吻合，并将主要关注 RAS 在发育、免疫和炎症方面的作用。 GRC 和 GRS 的主要目标是： 1) 严格审查将基础科学与 RAS 临床和转化研究相结合的前沿未发表数据； 2）在科学会议以及用餐、休息、休闲和社交活动期间，让所有参与者对研究结果进行无拘无束的坦率和分析性讨论，并对未来的影响进行创造性的思考； 3）促进新的合作和跨学科研究举措生物化学、分子和细胞生物学、神经科学、生理学和人类病理生理学等学科； 4) 通过 GRC 的海报会议、简短演讲和旅行奖竞赛以及由学生、实习生和年轻研究者专门组织的 GRS 提供曝光机会，促进学生、实习生和早期职业研究者的独立科学生涯。