The MIT Center for Single-Cell Dynamics in Cancer (SCDC)

麻省理工学院癌症单细胞动力学中心 (SCDC)

• 批准号: 8324014
• 负责人: SCOTT R MANALIS
• 金额: $ 282.43万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324014
• 关键词: Academic Medical Centers; Area; Biomedical Research; Boston; California; Cancer Biology; Cancer Model; Cell Separation; Cell division; Cells; Collaborations; Computer Simulation; Computing Methodologies; Data; Engineering; Genomics; Goals; Hospitals; In Vitro; Institutes; Institution; Instruction; Malignant - descriptor; Malignant Neoplasms; Massachusetts; Measurement; Medical; Modeling; Mutation; Netherlands; Normal Cell; Oncologist; Physics; Reagent; Research Personnel; San Francisco; Science; Signal Transduction; T-Cell Lymphoma; Technology; Tissues; Transcript; Universities; Woman; base; cancer cell; cancer therapy; cell growth; in vivo; medical schools; member; multidisciplinary; new technology; oncology; physical science; stem cell differentiation; tumor progression

The overall goal of this U54 application is to create and support a highly multidisciplinary team of expert oncologists, biologists, biochemists, engineers and both theoretical and experimental physicists. This team will form a Physical Science-Oncology Center (PS-OC) at the Massachusetts Institute of Technology for Single-Cell Dynamics in Cancer (SCDC). The overarching goal of this team is to use both theoretical and experimental approaches inspired by Physics and Engineering to attack important problems in cancer biology by developing novel technology and analytical/computational methods to track the dynamics of cancer at the single cell level. Most investigators from our team are affiliated with institutes in the Boston area including MIT, the Whitehead Institute for Biomedical Research, the Broad Institute of MIT and Harvard, Harvard Medical School, Brigham and Women's Hospital, and Boston University. Institutions from several other investigators are located at the West coast including the University of California, San Francisco and Stanford University. One of team members is located at the Hubrecht Institute and University Medical Center Utrecht in the Netherlands. The SCDC PS-OC will be based on close collaborations between investigators originating from three fields: cancer biology, experimental physics/engineering and theoretical/computational physics. In Project 1 single-cell transcript counting will be use to develop quantitative models of stem cell differentiation and reprogramming in healthy tissue and cancer. Project 2 utilizes complementary in silico, in vitro, and in vivo studies to deconvolute Ras signaling networks in T cell lymphoma. Project 3 will explore the coordination of cell growth and division in normal and cancer cells and Project 4 focuses on characterizing the load of driver and passenger mutations in cancer by modeling neoplastic progression and analyzing genomic data. All projects will make extensive of the Single-Cell Transcript Counting Core and the Cell Sorting and Physical Measurement Core. These facilities and all reagents generated by the cores will be made available to other PS-OCs.

该U54应用程序的总体目标是创建和支持高度多学科的肿瘤学家，生物学家，生物化学家，工程师以及理论和实验物理学家。该团队将在马萨诸塞州科技研究所组成一个物理科学肿瘤中心（PS-OC），用于癌症的单细胞动力学（SCDC）。该团队的总体目标是使用受物理和工程启发的理论和实验方法，通过开发新技术和分析/计算方法来攻击癌症生物学的重要问题，以跟踪单细胞水平上癌症的动态。来自我们团队的大多数调查员都隶属于波士顿地区的研究所，包括麻省理工学院，怀特海德生物医学研究所，麻省理工学院和哈佛大学广泛研究所，哈佛医学院，布里格姆和妇女医院以及波士顿大学。来自其他几个调查人员的机构位于西海岸，包括加利福尼亚大学，旧金山和斯坦福大学。团队成员之一位于荷兰的Hubrecht研究所和大学医学中心。 SCDC PS-OC将基于来自三个领域的研究人员之间的密切合作：癌症生物学，实验物理/工程和理论/计算物理学。在项目1中，单细胞转录本计数将用于开发健康组织和癌症中干细胞分化和重编程的定量模型。项目2利用了硅，体外研究中的互补研究，用于在T细胞淋巴瘤中脱卷RAS信号网络。项目3将探索正常和癌细胞中细胞生长和分裂的协调，项目4的重点是通过建模肿瘤进展并分析基因组数据来表征癌症驱动器和乘客突变的负载。所有项目都将广泛了解单细胞转录本计数核心以及细胞分类和物理测量核心。这些设施和核心产生的所有试剂将提供给其他PS-OC。