Supraspinal Contributions to Locomotor Control and Recovery after Stroke

脊柱上对中风后运动控制和恢复的贡献

• 批准号: 8018971
• 负责人: SHEILA M SCHINDLER-IVENS
• 金额: $ 11.72万
• 依托单位: MARQUETTE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8018971
• 关键词: Accounting; Acute; Age; Area; Beds; Bilateral; Brain; Brain imaging; Brain region; Cerebellum; Cerebral cortex; Cerebral hemisphere; Characteristics; Chronic Phase; Clinical; Clinical Trials; Detection; Development Plans; Event; Functional Magnetic Resonance Imaging; Funding; Goals; Hand; Human; Imaging technology; Impairment; Laboratories; Lead; Leg; Locomotion; Locomotor Recovery; Lower Extremity; Measures; Mentored Research Scientist Development Award; Mentors; Methods; Modeling; Morphologic artifacts; Motion; Motor; Movement; Participant; Phase; Physiological; Procedures; Process; Quality of life; Recovery; Rehabilitation Research; Rehabilitation therapy; Research; Research Project Grants; Scientist; Side; Signal Transduction; Stroke; Survivors; Techniques; Technology; Testing; Time; Training; Treatment Effectiveness; Upper Extremity; Walking; Work; acute stroke; base; blood oxygenation level dependent response; career; career development; chronic stroke; computerized data processing; design; effective therapy; hemiparesis; hemisphere damage; improved; insight; mind control; motor control; nerve injury; neuroadaptation; neuroregulation; novel; post stroke; post-doctoral training; programs; public health relevance; relating to nervous system; response; responsible research conduct; skills; somatosensory; success; tool

DESCRIPTION (provided by applicant): Advances in neural imaging technologies, such as functional magnetic resonance imaging (fMRI), have made it possible to examine human brain function during movement in people post stroke. As technologies advance and a better understanding of post-stroke brain function emerges, brain imaging may be used to predict treatment effectiveness and to identify physiological markers of recovery. These advances will be particularly helpful for locomotor rehabilitation, because impaired walking ability is a major obstacle to quality of life post stroke. However, technical challenges have made it difficult to image the brain during locomotor-like movements. The purpose of the research project proposed here is to use fMRI to understand how the brain controls locomotor-like movements of the lower extremities in people post stroke. Pedaling will be used as a model of locomotion. The PIs will test the hypotheses that impaired locomotor ability post stroke is associated with abnormally elevated pedaling-related brain activity in the cerebral cortex on the undamaged side of the brain and that improved locomotor ability is associated with a shift in the focus of brain activity to spared cortical regions on the damaged side of the brain and to the cerebellum. This is an application for a Mentored Research Scientist Development Award that will allow the applicant to develop the research skills required to pursue an independent, productive career in rehabilitation research. The applicant is a physical therapist with doctoral and postdoctoral training in rehabilitation research. Her long term goal is to lead an independent, nationally recognized laboratory that examines supraspinal control of locomotion in people with neural injury. This is an important, emerging area in motor control to which the candidate can make meaningful contributions across her career trajectory. The candidate will use her discoveries to develop and test rehabilitation activities that enhance locomotor recovery after stroke. This application includes a career development plan that builds on the applicant's existing skills in neural control of movement and provides additional training in functional brain imaging, supraspinal control of locomotion, the physiological basis of neural adaptation, design and analysis of clinical trials, and the responsible conduct of research. She has selected as mentors three established scientists (Drs. Brian Schmit, Kristina Ropella, and Jules Dewald) with expertise in relevant content areas and funded research programs. Each mentor has a strong commitment to her success. PUBLIC HEALTH RELEVANCE: Many stroke survivors fail to regain walking ability which leads to poor quality of life. A better understanding of how the brain controls locomotion many lead to more effective treatments. The results of this study will provide insight into how the post-stroke brain controls locomotion and may lead to novel treatments for improving locomotion after stroke.

描述（由申请人提供）：神经成像技术（例如功能性磁共振成像（fMRI））的进步使得检查中风后人运动期间的人脑功能成为可能。随着技术的进步和对中风后脑功能的更好理解的出现，脑成像可用于预测治疗效果并识别恢复的生理标志。这些进步对于运动康复特别有帮助，因为行走能力受损是中风后生活质量的主要障碍。然而，技术挑战使得在类似运动的过程中对大脑进行成像变得困难。这里提出的研究项目的目的是利用功能磁共振成像来了解大脑如何控制中风后患者下肢的类似运动。踏板将被用作运动模型。 PI 将测试这样的假设：中风后运动能力受损与大脑未受损一侧的大脑皮层中与踩踏相关的大脑活动异常升高有关，而运动能力的改善与大脑活动焦点的转移有关。大脑受损一侧的皮质区域和小脑幸免于难。这是一份指导研究科学家发展奖的申请，该奖将使申请人能够发展在康复研究领域追求独立、富有成效的职业所需的研究技能。申请人是一名物理治疗师，接受过康复研究博士和博士后培训。她的长期目标是领导一个独立的、国家认可的实验室，研究神经损伤患者的脊髓上运动控制。这是运动控制领域一个重要的新兴领域，候选人可以在其职业生涯中做出有意义的贡献。候选人将利用她的发现来开发和测试可增强中风后运动恢复的康复活动。该申请包括一份职业发展计划，该计划以申请人在运动神经控制方面的现有技能为基础，并提供功能性脑成像、脊髓上运动控制、神经适应的生理基础、临床试验的设计和分析以及负责人等方面的额外培训。进行研究。她选择了三位在相关内容领域和资助研究项目方面拥有专业知识的知名科学家（Brian Schmit、Kristina Ropella 和 Jules Dewald）作为导师。每位导师都对自己的成功做出了坚定的承诺。 公共卫生相关性：许多中风幸存者无法恢复行走能力，导致生活质量下降。更好地了解大脑如何控制运动可以带来更有效的治疗。这项研究的结果将深入了解中风后大脑如何控制运动，并可能带来改善中风后运动的新疗法。