Optics of the Growing Crystalline Lens

生长晶状体的光学原理

• 批准号: 8287865
• 负责人: FABRICE MANNS
• 金额: $ 44.61万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8287865
• 关键词: Ablation; Accounting; Adult; Affect; Age; Age-Years; Algorithms; Anterior; Biochemistry; Biomedical Engineering; Childhood; Clinical; Computer Simulation; Contact Lenses; Cornea; Corneal Topography; Cross-Sectional Studies; Crystalline Lens; Data; Development; Disease; Engineering; Equilibrium; Eye; Goals; Growth; Health; Human; Image; In Vitro; Intraocular lens implant device; Knowledge; Lasers; Length; Lens Fiber; Life; Longevity; Measurement; Measures; Methods; Modeling; Myopia; Ocular Refraction; Ophthalmology; Optical Coherence Tomography; Optics; Optometry; Outcome; Output; Performance; Peripheral; Physiological; Procedures; Refractive Errors; Refractive Indices; Research; Research Personnel; Research Project Grants; Role; Shapes; Stretching; Surface; System; Techniques; Testing; Theoretical model; Vision; Visual; age related; computerized tools; design; fiber cell; image processing; improved; in vivo; indexing; interest; lens; novel strategies; prevent; response

DESCRIPTION (provided by applicant): The objective of this project, submitted in response to PA-10-009, Bioengineering Research Grants, is to understand how the continuous growth of the crystalline lens throughout the life span contributes to changes in the optical quality of the eye. The main hypotheses to be tested are: (1) Changes in the lens refractive index gradient due to the lens fiber cell compaction that occurs with lens growth are correlated with age-related changes in lens power and spherical aberration. (2) These changes account for the progressive loss of balance between corneal and internal ocular aberrations. The proposal has three specific Aims: Aim 1: To develop an age-dependent optical model of the crystalline lens with refractive index gradient New experimental methods will be developed to measure the refractive index gradient, refractive power and aberrations of the in vitro lens using optical coherence tomography. Once validated, these techniques will be used to quantify the optical parameters of the in vitro lens as a function of age. The data will be used to develop theoretical models and computational tools to model the changes in refractive index gradient due to lens growth and predict how these changes modify the power and aberrations of the crystalline lens. Aim 2: To quantify the contribution of the lens shape and refractive index gradient to ocular spherical aberration in vivo. The methods of Aim 1 will be extended to retrieve the in vivo lens index gradient, power, and spherical aberration from optical coherence tomography images of the anterior segment. The optical parameters of the in vivo human lens will be measured as a function of age to determine the role of lens growth on the spherical aberration of the lens and the balance between corneal and internal aberrations. Aim 3: To evaluate the contribution of the lens shape and refractive index gradient to the peripheral optics of the eye. We will apply our model by evaluating the contribution of the crystalline lens to the peripheral optical performance of the eye. The model lens will then be integrated into a whole eye model that will output the peripheral refraction and off-axis aberration in the relaxed and accommodated states, as a function of age. The data will be used to test the prediction that lens growth and accommodative changes produce changes in the peripheral refraction and off axis aberrations of the whole eye. The project will have a broad impact on the field of physiological optics at a fundamental level. Quantifying how lens power and aberrations change with age will help better understand refractive error and aberration development. By characterizing the contribution of lens growth to the ocular aberration state, the results will also help better predict the long-term outcome of aberration-guided vision correction procedures, and help design improved treatments that take into account age-changes in the lens to improve the long-term visual outcome. PUBLIC HEALTH RELEVANCE: The crystalline lens of the eye continuously grows throughout life. This growth is a factor in the development of refractive errors, such as myopia. It also produces changes in the optical quality of the lens which can negatively affect the long-term outcome of vision correction procedures. The goal of the project is to better understand how the continuous growth of the crystalline lens changes the optical quality of the eye. The project will help better understand refractive error development, help develop better treatments to prevent the development of refractive errors, and help design improved vision correction treatments.

描述（由申请人提供）：该项目的目的是针对PA-10-009（生物工程研究补助金）提交的，是要了解整个生命周期中晶体的持续增长如何有助于眼睛光学质量的变化。 要测试的主要假设是：（1）由于晶状体纤维细胞压实而发生的透镜纤维细胞压实，随着晶状体生长的发生而导致的透镜折射率梯度的变化与透镜的功率和球形异常的变化相关。 （2）这些变化解释了角膜和内部眼部畸变之间的平衡逐渐丧失。该提案具有三个特定的目的：目标1：将开发具有折射率梯度的结晶镜的光学模型，将开发出新的实验方法，以测量使用光学相干学术的折射率梯度，屈光能力和体外晶状体的异常。一旦验证，这些技术将用于量化体外镜头的光学参数作为年龄的函数。数据将用于开发理论模型和计算工具，以模拟由于晶状体增长而导致的折射率梯度变化，并预测这些变化如何改变晶体镜头的功率和畸变。目标2：量化晶状体形状和折射率梯度对体内眼球异常的贡献。 AIM 1的方法将扩展以从前段的光学相干断层扫描图像中检索体内镜头指数梯度，功率和球形像差。体内人晶状体的光学参数将作为年龄的函数测量，以确定晶状体生长在镜头球形像差以及角膜和内部畸变之间的平衡。 AIM 3：评估镜头形状和折射率梯度对眼睛外周光学的贡献。我们将通过评估晶体对眼睛外周光学性能的贡献来应用模型。然后将模型镜头集成到整个眼模型中，该模型将在宽松和容纳的状态下输出外围折射和轴畸变，这是年龄的函数。数据将用于测试镜头生长和适应性变化会导致周围折射和整个眼睛的轴线畸变的变化的预测。该项目将对基本水平的生理光学领域产生广泛的影响。量化晶状体功率和畸变如何随着年龄的变化而变化将有助于更好地理解折射率和畸变的发展。通过表征晶状体生长对眼像畸变状态的贡献，结果还将有助于更好地预测像差引导视力校正程序的长期结果，并帮助设计改进的治疗方法，这些治疗方法考虑了镜头中的年龄变化，以改善长期视觉结果。 公共卫生相关性：眼睛的结晶镜头一生都在不断增长。这种增长是折射错误（例如近视）发展的因素。它还产生镜头光学质量的变化，可能会对视力校正程序的长期结果产生负面影响。该项目的目的是更好地了解结晶镜的持续生长如何改变眼睛的光学质量。该项目将有助于更好地理解屈光不确定的错误发展，有助于开发更好的治疗方法以防止折射错误的发展，并帮助设计改进的视力校正治疗方法。