Core 3: Neuro-Imaging Core

核心 3：神经影像核心

• 批准号: 8269757
• 负责人: Ravi Bansal
• 金额: $ 31.5万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8269757
• 关键词: Address; Adolescent; Adult; Age; Animal Model; Animals; Archives; Behavioral; Brain; Brain imaging; Brain region; Center for Translational Science Activities; Child; Computers; Data; Data Analyses; Development; Diffusion Magnetic Resonance Imaging; Electroencephalography; Ensure; Faculty; Genes; Genetic; Genotype; Human; Image; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mediator of activation protein; Methods; Multimodal Imaging; Mus; Newborn Infant; Participant; Performance; Perfusion Weighted MRI; Physiologic pulse; Population; Procedures; Process; Productivity; Research; Research Project Grants; Scientist; Serotonin; Signal Transduction; Staging; Statistical Methods; System; Training; behavior measurement; brain behavior; data integrity; density; imaging modality; infancy; neuroimaging; quality assurance

The Neuroimaging core will acquire and process multimodal imaging data to enhance significantly our understanding of the effects of serotonergic signaling in the brain. It will provide the extensive expertise of its faculty and staff for conducting brain imaging research in mice, newborn babies, children, and adolescents using structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), perfusion MRI, MR spectroscopy (MRS), and high density EEG. By applying validated and reliable imaging and statistical methods, the core will ensure uniformity, consistency, and economy of scale across all projects of the center. The Core will contribute significantly to accelerate our understanding of the disturbances in the brain caused by serotonin availability at various stages during eariy brain development. To quantify disturbances in various cortical and subcortical brain circuits, research projects will acquire and analyze multimodal MR data, and compute various brain measures, including EEG power and coherence, local volumes of brain regions, and between-region connectivity. These measures will be correlated with genotype data to discern the gene-brain-behavior correlates across species, and age ranges from infancy to adulthood. Furthermore, the core will ensure data integrity by (1) quantifying identical brain measures using the same imaging and statistical methods across all projects; (2) rigorously evaluating methods developed to address better the challenges in analyzing data from a wide age range of participants; and (3) exploiting economy of scale by applying common components of image and statistical analyses across all projects, thereby greatly enhancing the efficiency and productivity of the center.

神经成像核心将采集和处理多模态成像数据，以显着增强我们对大脑中血清素信号传导影响的理解。它将提供其教职员工的广泛专业知识，用于对小鼠、新生儿、儿童和青少年进行脑成像研究 使用结构磁共振成像 (MRI)、扩散张量成像 (DTI)、灌注 MRI、磁共振波谱 (MRS) 和高密度脑电图。通过应用经过验证且可靠的成像和统计方法，该核心将确保该中心所有项目的一致性、一致性和规模经济性。 该核心将极大地促进我们对早期大脑发育过程中各个阶段血清素可用性引起的大脑干扰的理解。为了量化各种皮质和皮质下脑回路的干扰，研究项目将获取并分析多模态 MR 数据，并计算各种大脑测量值，包括脑电图功率和一致性、大脑区域的局部体积以及区域间的连接性。这些测量将与基因型数据相关联，以辨别跨物种和从婴儿期到成年的年龄范围的基因-大脑行为的相关性。此外，核心将通过以下方式确保数据完整性：（1）使用相同的成像和技术来量化相同的大脑测量值 所有项目的统计方法； (2) 严格评估为更好地应对分析来自广泛年龄范围的参与者的数据的挑战而开发的方法； (3) 通过在所有项目中应用图像和统计分析的通用组件来利用规模经济，从而大大提高该中心的效率和生产力。