TOPICAL MICROBICIDE AGAINST SIV AND CHLAMYDIA

针对 SIV 和衣原体的局部杀菌剂

• 批准号: 8358219
• 负责人: ASHLEY T. HAASE
• 金额: $ 19.9万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358219
• 关键词: Animals; Chlamydia; Chronic; Funding; Grant; HIV; HIV Infections; Health Services Research; Local Microbicides; Macaca mulatta; Modeling; National Center for Research Resources; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Research Personnel; Resources; SIV; Services; Source; Testing; United States National Institutes of Health; Wisconsin; Woman; combat; cost; efficacy testing; glycerol monolaurate; in vivo; microbicide; news; nonhuman primate; prevent; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To test the efficacy of a potential microbicidal agent to prevent transmission of HIV to women. Such an effective agent is urgently needed to combat the predominant rise globally of new HIV infections in women. This proposal tested in vivo the efficacy of glycerol monolaurate to prevent intravaginal transmission of simian immunodeficiency virus to rhesus macaques, a highly relevant nonhuman primate model of sexual mucosal transmission of HIV. We found that glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginallactobacilli and is safe for chronic use. The project used Animal Services and Research Services. News Item, March 4, 2010: Researchers identify compound that could prevent HIV transmission http://www.ahc.umn.edu/research/corridors/infectiousdisease/gml/ PUBLICATIONS: None this reporting period.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 目的：测试潜在杀菌剂预防艾滋病毒传播给女性的功效。 迫切需要这样一种有效的药物来应对全球女性新发艾滋病毒感染人数的大幅上升。该提案在体内测试了单月桂酸甘油酯预防猿猴免疫缺陷病毒阴道内传播给恒河猴的功效，恒河猴是艾滋病毒性粘膜传播的一种高度相关的非人灵长类动物模型。我们发现单月桂酸甘油酯不会改变恒河猴（Macaca mulatta）阴道乳酸杆菌，并且长期使用是安全的。 该项目使用动物服务和研究服务。 新闻，2010 年 3 月 4 日：研究人员发现了可以预防 HIV 传播的化合物 http://www.ahc.umn.edu/research/corridors/infectiousdisease/gml/ 出版物： 本报告期无。