CELLULAR IMMUNE RESPONSES IN SIV-INFECTED SOOTY MANGABEYS

感染 SIV 的乌白眉猴的细胞免疫反应

• 批准号: 8357908
• 负责人: Amitinder Kaur
• 金额: $ 19.54万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357908
• 关键词: Biological Assay; CD8-Positive T-Lymphocytes; Cercocebus atys; Funding; Grant; Immune response; Infection; Lymphocyte Depletion; National Center for Research Resources; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; SIV; Source; Staining method; Stains; United States National Institutes of Health; base; cost; cytokine; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The role of SIV-specific cellular immune responses in maintaining nonpathogenic SIV infection in sooty mangabeys is being investigated in SIV-infected sooty mangabeys using Elispot and intracellular cytokine staining assays as well as by in vivo CD8-positive T lymphocyte depletion studies.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 正在研究使用ELISPOT和细胞内细胞因子染色测定法以及通过体内CD8阳性T淋巴细胞depletete研究研究中SIV特异性细胞免疫反应在SIV感染的烟囱中维持非对病毒SIV感染中的作用。