CIRCADIAN CLOCK MECHANISMS IN THE BRAIN AND PERIPHERAL ORGANS

大脑和周围器官的昼夜节律机制

• 批准号: 8357866
• 负责人: HENRYK F URBANSKI
• 金额: $ 1.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357866
• 关键词: Affect; Aging; Body part; Brain; Brain region; Circadian Rhythms; Funding; Genes; Grant; Human; Learning; Macaca mulatta; Methodology; National Center for Research Resources; Organ; Peripheral; Photoperiod; Physiology; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Reverse Transcriptase Polymerase Chain Reaction; School Teachers; Science; Source; Training; United States National Institutes of Health; circadian pacemaker; cost; high school; meetings; sleep onset; suprachiasmatic nucleus; teacher

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Many aspects of human physiology, including onset of sleep, are thought to be controlled by a circadian clock located in the suprachiasmatic nucleus of the brain. However, there is now compelling evidence that other oscillator circuits may also be involved. This "Partners-in-Science" project gives a high-school teacher the opportunity to examine how different brain regions and different peripheral organs regulate circadian physiology in rhesus macaques. Specifically, he is learning how to analyze GeneChip microarrays and how to perform RT-PCR. These methodologies will enable him to examine how the expression of clock-related genes in different parts of the body is affected by aging and changes in photoperiod. The teacher completed the first year of his 2-year training and recently presented some of his results at the annual national Partners-in-Science meeting.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 人类生理学的许多方面，包括睡眠的发作，被认为是由位于大脑上核核中的昼夜节律控制的。但是，现在有令人信服的证据表明其他振荡器电路也可能涉及。这个“科学合作伙伴”项目为一名高中老师提供了机会，有机会研究不同的大脑区域和不同的外围器官如何调节恒河猕猴的昼夜节律生理学。具体而言，他正在学习如何分析Genechip微阵列以及如何执行RT-PCR。这些方法将使他能够研究身体不同部位中时钟相关基因的表达如何受到衰老和光周期变化的影响。老师完成了为期两年的培训的第一年，并最近在年度国家合作伙伴会议上介绍了他的一些结果。