Ovarian Cancer

卵巢癌

• 批准号: 8250268
• 负责人: Shelley S Tworoger
• 金额: $ 16.71万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8250268
• 关键词: Acrylamides; Address; Adolescence; Adult; Age; Alleles; Anthocyanidin; Biological; Biological Markers; Blood; Blood specimen; Body mass index; Cancer Etiology; Cause of Death; Cessation of life; Dairy Products; Data; Data Analyses; Databases; Diagnosis; Diagnostic; Dietary Factors; Dietary intake; Disease; Environment; Epidemiologic Studies; Epithelial ovarian cancer; Erythrocytes; Estrogen Receptors; Etiology; Flavanones; Flavones; Flavonoids; Flavonols; Genital system; Goals; Health Personnel; Height; Hormonal; Hormonal Risk Factor; Hormone Receptor; Hormones; Incidence; Infertility; Inflammation; Inflammatory; Intake; Interleukin-6; Intervention; Investigation; Lactose; Lead; Leadership; Life Style; MAP Kinase Gene; Maintenance; Malignant Neoplasms; Malignant neoplasm of ovary; Measures; Melatonin; Menopausal Status; Modeling; Morbidity - disease rate; Mucin-1 Staining Method; Neoplasm Metastasis; Nurses' Health Study; Nutritional; Obesity; Ovarian; Overweight; PTGS2 gene; Paraffin Embedding; Participant; Pathway interactions; Peritoneal; Plasma; Postmenopause; Premenopause; Prevention; Preventive; Proanthocyanidins; Proteins; Questionnaires; RXR; Receptor Gene; Research Infrastructure; Risk; Risk Factors; Role; STAT3 gene; Sampling; Serous; Specimen; TNF gene; Talc; Time; Tubal Ligation; Tumor Markers; Tumor Tissue; Urine; Veins; Vitamin D; Vitamin D3 Receptor; Woman; Work; Wound Healing; adduct; base; cancer risk; carcinogenesis; cohort; flavan-3-ol; flavanone; flavone; follow-up; improved; inflammatory marker; lifestyle factors; mortality; ovarian neoplasm; progesterone receptor negative; reproductive; shift work; tool; tumor; urinary

In this Project, we propose to continue the investigation of potentially modifiable nutritional and hormonal risk factors for incident ovarian cancer. This work will use prospectively collected questionnaire data, biological samples, and paraffin-embedded ovarian tumor tissue from women in the Nurses' Health Study (NHS) and NHSII. Although several hypotheses regarding ovarian cancer etiology have been proffered, few modifiable lifestyle risk factors have been identified. We will examine the possible preventive role of vitamin D in ovarian cancer, with the goal of identifying subpopulations who could most benefit from intervention. We also will evaluate three dietary factors: flavonoids, which may reduce risk; lactose in adolescence and adulthood; and acrylamide intake and red blood cell adduct levels, both of which may increase risk. We also will evaluate the role of melatonin and shift work in ovarian carcinogenesis. In addition, we propose to measure circulating markers of inflammation (CPR, IL-6, and TNFa-R2) and tumor markers associated with inflammation (e.g., STATs). We also propose for the first time to focus specifically on fatal ovarian cancer, with an effort to identify risk factors that may predispose women to either having fast-growing tumors or a peritoneal environment susceptible to metastasis. In this same vein, we plan to evaluate hormone receptors in ovarian tumors and their relation to risk factors, with an emphasis on exploring a new model of ovarian carcinogenesis (slow-growing tumors vs. fast-growing tumors) as a way to classify tumors in epidemiologic studies. The Project shares common biological themes with Projects 1 and 2, including the role of vitamin D, melatonin, and the inflammation pathway and interacts closely with Project 4 for methodologic issues. It also shares with the other Projects a strong administrative and scientific infrastructure provided by Cores A (cohort follow-up and data base maintenance), B (confirmation of cancer and cause of death), C (management of the biospecimens) and D (leadership and data analysis). The findings should enhance understanding of the etiology and progression of ovarian cancer and provide guidance for women and their health care providers in their efforts to reduce suffering and death from this disease.

在这个项目中，我们建议继续研究潜在的可修改营养和荷尔蒙风险 发生卵巢癌的因素。这项工作将使用前瞻性收集的问卷数据，生物学 在护士健康研究（NHS）和 NHSII。尽管已经提出了一些关于卵巢癌病因的假设，但很少有可修改 已经确定了生活方式风险因素。我们将检查维生素D在 卵巢癌，目的是确定可以从干预中受益最大的亚群。我们 还将评估三个饮食因素：类黄酮，可以降低风险；乳糖在青春期和 成年以及丙烯酰胺的摄入量和红细胞加合物水平，这两者都可能增加风险。我们也是 将评估褪黑激素和转移工作在卵巢癌发生中的作用。此外，我们建议 测量炎症的循环标记（CPR，IL-6和TNFA-R2）和肿瘤标记 炎症（例如统计数据）。我们还首次建议专门专门研究致命的卵巢癌， 为了确定可能使女性患有快速增长肿瘤或A的危险因素 腹膜环境容易转移。同样，我们计划评估激素受体 在卵巢肿瘤及其与危险因素的关系中，重点是探索一种新的卵巢模型 致癌作用（缓慢增长的肿瘤与快速增长的肿瘤）作为一种在流行病学中分类的方式 研究。该项目与项目1和2共有共同的生物学主题，包括维生素D的作用， 褪黑激素以及炎症途径，并与项目4紧密相互作用，以解决方法论问题。也是如此 与其他项目分享核心A提供的强大行政和科学基础设施 （队列随访和数据基础维护），B（癌症的确认和死亡原因），C （生物测量的管理）和D（领导力和数据分析）。调查结果应增强 了解卵巢癌的病因和进展，并为妇女及其提供指导 医疗保健提供者为减少这种疾病的痛苦和死亡而努力。